HEPACAM2

HEPACAM2

HEPACAM2

Protein-coding gene in the species Homo sapiens

HEPACAM family member 2 is a protein that in humans is encoded by the HEPACAM2 gene. [5]

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Function

This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology, and apoptosis.

Poly (ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients.

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000188175 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000044156 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: HEPACAM family member 2". Retrieved 2017-09-13.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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