Glutaryl-CoA_dehydrogenase_(non-decarboxylating)

Glutaryl-CoA dehydrogenase (non-decarboxylating)

Glutaryl-CoA dehydrogenase (non-decarboxylating)

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Glutaryl-CoA dehydrogenase (non-decarboxylating) (EC 1.3.99.32, GDHDes, nondecarboxylating glutaryl-coenzyme A dehydrogenase, nondecarboxylating glutaconyl-coenzyme A-forming GDH) is an enzyme with systematic name glutaryl-CoA:acceptor 2,3-oxidoreductase (non-decarboxylating).[1][2] This enzyme catalyses the following chemical reaction

glutaryl-CoA + acceptor (E)-glutaconyl-CoA + reduced acceptor
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The enzyme contains FAD.

References

  1. [1]
    Wischgoll S, Taubert M, Peters F, Jehmlich N, von Bergen M, Boll M (July 2009). "Decarboxylating and nondecarboxylating glutaryl-coenzyme A dehydrogenases in the aromatic metabolism of obligately anaerobic bacteria". Journal of Bacteriology. 191 (13): 4401–9. doi:10.1128/JB.00205-09. PMC 2698508. PMID 19395484.
  2. [2]
    Wischgoll S, Demmer U, Warkentin E, Günther R, Boll M, Ermler U (June 2010). "Structural basis for promoting and preventing decarboxylation in glutaryl-coenzyme a dehydrogenases". Biochemistry. 49 (25): 5350–7. doi:10.1021/bi100317m. PMID 20486657.
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