Gammaretrovirus_core_encapsidation_signal

Gammaretrovirus core encapsidation signal

Gammaretrovirus core encapsidation signal

Add article description

The Gammaretrovirus core encapsidation signal is an RNA element known to be essential for stable dimerisation and efficient genome packaging during virus assembly.[1] Dimerisation of the viral RNA genomes is proposed to act as an RNA conformational switch which exposes conserved UCUG elements and enables efficient genome encapsidation.[2] The structure of this element is composed of three stem-loops. Two of the stem-loops called SL-C and SL-D form a single co-axial extend helix.

Quick Facts Identifiers, Symbol ...
A 3D representation of a Gammaretrovirus core encapsidation signal. This is a view of the NMR structure for the 101-nucleotide core encapsidation signal of the Moloney murine leukemia virus.[1]
A 3D representation of a Gammaretrovirus. This structure shows the packaging of the dimeric genome of Moloney murine leukaemia virus, of which the encapsidation signal forms a part.[2]

See also

References

  1. [1]
    D'Souza V, Dey A, Habib D, Summers MF (2004). "NMR structure of the 101-nucleotide core encapsidation signal of the Moloney murine leukemia virus". J Mol Biol. 337 (2): 427–442. doi:10.1016/j.jmb.2004.01.037. PMID 15003457.
  2. [2]
    D'Souza V, Summers MF (2004). "Structural basis for packaging the dimeric genome of Moloney murine leukaemia virus". Nature. 431 (7008): 586–590. Bibcode:2004Natur.431..586D. doi:10.1038/nature02944. PMID 15457265. S2CID 4409362.


Stub icon

This molecular or cell biology article is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article Gammaretrovirus_core_encapsidation_signal, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.