Gamma-Melanocyte-stimulating_hormone

<i>gamma</i>-Melanocyte-stimulating hormone

gamma-Melanocyte-stimulating hormone

Chemical compound

γ-Melanocyte-stimulating hormone (γ-MSH) is an endogenous peptide hormone and neuropeptide.[1] It is a melanocortin, specifically, one of the three types of melanocyte-stimulating hormone (MSH), and is produced from proopiomelanocortin (POMC).[1] It is an agonist of the MC1, MC3, MC4, and MC5 receptors.[1] It exists in three forms, γ1-MSH, γ2-MSH, and γ3-MSH.[2]

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γ-MSH regulated cardiovascular functions. γ-MSH effects are measured through the effects it has on the central neural pathway dispersed throughout the kidney.[3] It is not moderated based on tubular sodium transport. Gamma-MSH activates MC3R in renal tubular cells by limiting sodium absorption by inhibiting the central neural pathway.[3] This regulates sodium balance and blood pressure. If MC3R is absent then there is resistance in γ-MSH which results in hypertension on HSD.[4]

See also

References

  1. [1]
    Kastin A (26 January 2013). Handbook of Biologically Active Peptides. Academic Press. pp. 838–844. ISBN 978-0-12-385096-6.
  2. [2]
    Jakubke HD, Sewald N (8 September 2008). Peptides from A to Z: A Concise Encyclopedia. John Wiley & Sons. pp. 216–. ISBN 978-3-527-62117-0.
  3. [3]
    Kathpalia PP, Charlton C, Rajagopal M, Pao AC (May 2011). "The natriuretic mechanism of Gamma-Melanocyte-Stimulating Hormone". Peptides. 32 (5): 1068–1072. doi:10.1016/j.peptides.2011.02.006. PMC 3112371. PMID 21335042.
  4. [4]
    Reudelhuber TL (April 2003). "Salt-sensitive hypertension: if only it were as simple as rocket science". The Journal of Clinical Investigation. 111 (8): 1115–1116. doi:10.1172/jci200316993. PMC 152948. PMID 12697727.
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