GTF2A1L

GTF2A1L

GTF2A1L

Protein-coding gene in the species Homo sapiens

TFIIA-alpha and beta-like factor is a protein that in humans is encoded by the GTF2A1L gene.[4][5][6][7]

Quick Facts Identifiers, Aliases ...

The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of TFIIA on the interaction between TATA-binding protein (TBP) and DNA.

This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified.

Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.[7]

References

  1. [1]
    GRCm38: Ensembl release 89: ENSMUSG00000024154 – Ensembl, May 2017
  2. [2]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. [3]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    Upadhyaya AB, Lee SH, DeJong J (Jul 1999). "Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis". J Biol Chem. 274 (25): 18040–8. doi:10.1074/jbc.274.25.18040. PMID 10364255.
  5. [5]
    Xie W, Han S, Khan M, DeJong J (May 2002). "Regulation of ALF gene expression in somatic and male germ line tissues involves partial and site-specific patterns of methylation". J Biol Chem. 277 (20): 17765–74. doi:10.1074/jbc.M200954200. PMID 11889132.
  6. [6]
    Huang M, Wang H, Li J, Zhou Z, Du Y, Lin M, Sha J (Mar 2006). "Involvement of ALF in human spermatogenesis and male infertility". Int J Mol Med. 17 (4): 599–604. doi:10.3892/ijmm.17.4.599. PMID 16525715.
  7. [7]
    "Entrez Gene: ALF TFIIA-alpha/beta-like factor".

Further reading


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