GSK3A
GSK3A
Protein-coding gene in the species Homo sapiens
Glycogen synthase kinase-3 alpha is an enzyme that in humans is encoded by the GSK3A gene.[5]
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Glycogen synthase kinase 3-alpha EC 2.7.1.37 is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase and various transcription factors (e.g., JUN). It also plays a role in the WNT and phosphoinositide 3-kinase (especially PIK3CG) signaling pathways.[6][7]
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Shaw PC, Davies AF, Lau KF, Garcia-Barcelo M, Waye MM, Lovestone S, Miller CC, Anderton BH (Oct 1998). "Isolation and chromosomal mapping of human glycogen synthase kinase-3 alpha and -3 beta encoding genes". Genome. 41 (5): 720–7. doi:10.1139/gen-41-5-720. PMID 9809441.
- Ali A, Hoeflich KP, Woodgett JR (Aug 2001). "Glycogen synthase kinase-3: properties, functions, and regulation". Chemical Reviews. 101 (8): 2527–40. doi:10.1021/cr000110o. PMID 11749387.
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