GDF7

GDF7

GDF7

Protein-coding gene in the species Homo sapiens

Growth differentiation factor 7 (GDF7) is a protein that in humans is encoded by the GDF7 gene.[5]

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GDF7 belongs to the transforming growth factor beta superfamily that is specifically found in a signaling center known as the roof plate that is located in the developing nervous system of embryos. The roof plate is required for the generation of several classes of spinal cord dorsal interneurons; GDF7 specifically induces the formation of sensory neurons in the dorsal spinal cord from neural crest cells by generating signals within the roof plate.[5][6]

GDF7 is also known as bone morphogenic protein 12 (BMP-12).[7]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000143869 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000037660 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Lee KJ, Mendelsohn M, Jessell TM (November 1998). "Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord". Genes Dev. 12 (21): 3394–407. doi:10.1101/gad.12.21.3394. PMC 317230. PMID 9808626.
  6. [6]
    Lo L, Dormand E, Anderson D (2005). "Late-emigrating neural crest cells in the roof plate are restricted to a sensory fate by GDF7". Proc Natl Acad Sci USA. 102 (20): 7192–7. Bibcode:2005PNAS..102.7192L. doi:10.1073/pnas.0502581102. PMC 1091754. PMID 15883363.
  7. [7]
    Peng C, Lei C, Guofei C, Tian Y, Wei L, Jianwei Z, Chen W, Wentao Z, Changqing J (2019). "The application of BMP-12-overexpressing mesenchymal stem cells loaded 3D-printed PLGA scaffolds in rabbit rotator cuff repair". International Journal of Biological Macromolecules. 138: 79–88. doi:10.1016/j.ijbiomac.2019.07.041. PMID 31295489. S2CID 195892657.

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