Francisco de la Serna, O.E.S.A. (1568 – April 1647) was a Roman Catholic prelate who served as Bishop of La Paz (1645–1647), Bishop of Popayán (1638–1645), and Bishop of Paraguay (1635–1638).^[1]

Francisco de la Serna was born in Huanuco, Peru in 1568 and ordained a priest in the Order of Hermits of Saint Augustine on 9 June 1596.^[2][3] On 17 December 1635, he was appointed during the papacy of Pope Urban VIII as Bishop of Paraguay.^[1][2][3] On 15 November 1637, he was consecrated bishop by Hernando de Arias y Ugarte, Archbishop of Lima, assisted by Father Pedro de Ortega y Sotomayor.^[2][3] On 14 June 1638, he was appointed during the papacy of Pope Urban VIII as Bishop of Popayán.^[1][2][3] On 19 January 1645, he was selected by the King of Spain and confirmed by Pope Innocent X on 21 August 1645 as Bishop of La Paz.^[1][2][3] He died in April 1647.^[1][2][3]

While bishop, he was the principal consecrator of Gaspar de Villarroel, Bishop of Santiago de Chile (1638); and the principal co-consecrator of Bartolomé de Benavente y Benavides, Bishop of Antequera, Oaxaca (1640).^[2]