Formate_dehydrogenase-N

Formate dehydrogenase-N

Formate dehydrogenase-N

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Formate dehydrogenase-N (EC 1.1.5.6, Fdh-N, FdnGHI, nitrate-inducible formate dehydrogenase, formate dehydrogenase N, FDH-N, nitrate inducible Fdn, nitrate inducible formate dehydrogenase) is an enzyme with systematic name formate:quinone oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction

formate + quinone CO2 + quinol
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This enzyme contains molybdopterin-guanine dinucleotides, five [4Fe-4S] clusters and two heme b groups.

References

  1. [1]
    Enoch HG, Lester RL (September 1975). "The purification and properties of formate dehydrogenase and nitrate reductase from Escherichia coli". The Journal of Biological Chemistry. 250 (17): 6693–705. PMID 1099093.
  2. [2]
    Jormakka M, Törnroth S, Byrne B, Iwata S (March 2002). "Molecular basis of proton motive force generation: structure of formate dehydrogenase-N". Science. 295 (5561): 1863–8. doi:10.1126/science.1068186. PMID 11884747.
  3. [3]
    Jormakka M, Törnroth S, Abramson J, Byrne B, Iwata S (January 2002). "Purification and crystallization of the respiratory complex formate dehydrogenase-N from Escherichia coli". Acta Crystallographica Section D. 58 (Pt 1): 160–2. doi:10.1107/s0907444901017723. PMID 11752799.
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