FCGR1A

FCGR1A

FCGR1A

Mammalian protein found in Homo sapiens

High affinity immunoglobulin gamma Fc receptor I is a protein that in humans is encoded by the FCGR1A gene.[5][6][7]

Quick Facts Available structures, PDB ...

Interactions

The FcgRI binds the Fc portion of IgG and causes activation of the host cell via an intercellular ITAM motif.[8]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000150337 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000015947 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Maresco DL, Chang E, Theil KS, Francke U, Anderson CL (September 1996). "The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21". Cytogenetics and Cell Genetics. 73 (3): 157–63. doi:10.1159/000134330. PMID 8697799.
  6. [6]
    Maresco DL, Blue LE, Culley LL, Kimberly RP, Anderson CL, Theil KS (November 1998). "Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1". Cytogenetics and Cell Genetics. 82 (1–2): 71–4. doi:10.1159/000015067. PMID 9763663. S2CID 20290009.
  7. [7]
    "Entrez Gene: FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)".
  8. [8]
    The function of Fcγ receptors in dendritic cells and macrophages Martin Guilliams Pierre Bruhns Yvan Saeys Hamida Hammad and Bart N. Lambrecht FEBRUARY 2014 | VOLUME 14 Nature Reviews Immunology

Further reading

  • Overview of all the structural information available in the PDB for UniProt: P12314 (Human High affinity immunoglobulin gamma Fc receptor I (FCGR1A)) at the PDBe-KB.


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