F-box_protein_40

F-box protein 40

F-box protein 40

Protein-coding gene in the species Homo sapiens

F-box protein 40 is a protein that in humans is encoded by the FBXO40 gene. Fbxo40 induces ubiquitination of IRS1, thus limiting activity of IGF1 signaling (Shi et al, 2011).[5][6]

Quick Facts FBXO40, Identifiers ...

Function

Members of the F-box protein family, such as FBXO40, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.[7]

Fbxo40 in particular engages a unique substrate, IRS1, which is a protein in the IGF1 signaling pathway. In this way, Fbxo40 causes ubiquitination and degradation of IRS1, blocking further signaling downstream of the IGF1 receptor.[5]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000163833 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000047746 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Shi J, Luo L, Eash J, Ibebunjo C, Glass DJ (November 2011). "The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling". Dev Cell. 21 (5): 835–47. doi:10.1016/j.devcel.2011.09.011. PMID 22033112.
  6. [6]
    "Entrez Gene: F-box protein 40". Retrieved 2017-11-24.
  7. [7]
    Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW (November 2004). "Systematic analysis and nomenclature of mammalian F-box proteins". Genes & Development. 18 (21): 2573–80. doi:10.1101/gad.1255304. PMC 525538. PMID 15520277.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Stub icon

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article F-box_protein_40, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.