Epicatechin_gallate

Epicatechin gallate

Epicatechin gallate

Chemical compound

Not to be confused with EGCG.

Epicatechin gallate (ECG) is a flavan-3-ol, a type of flavonoid, present in green tea.[1] It is also reported in buckwheat[2] and in grape.[3]

Quick Facts Names, Identifiers ...

The tea component epicatechin gallate is being researched because in vitro experiments showed it can reverse methicillin resistance in bacteria such as Staphylococcus aureus.[1] Nevertheless, the compound is significantly degraded by steeping in boiling water, unlike related catechins.[4]

Epicatechin, as well as many other flavonoids, has been found to act as a non-selective antagonist of the opioid receptors, albeit with somewhat low affinity.[5]

References

  1. [1]
    Shiota, S; Shimizu, M; Mizushima, T; Ito, H; Hatano, T; Yoshida, T; Tsuchiya, T (1999). "Marked reduction in the minimum inhibitory concentration (MIC) of beta-lactams in methicillin-resistant Staphylococcus aureus produced by epicatechin gallate, an ingredient of green tea (Camellia sinensis)". Biological & Pharmaceutical Bulletin. 22 (12): 1388–90. doi:10.1248/bpb.22.1388. PMID 10746177.
  2. [2]
    Danila, Ana-Maria; Kotani, Akira; Hakamata, Hideki; Kusu, Fumiyo (2007). "Determination of Rutin, Catechin, Epicatechin, and Epicatechin Gallate in BuckwheatFagopyrum esculentumMoench by Micro-High-Performance Liquid Chromatography with Electrochemical Detection". Journal of Agricultural and Food Chemistry. 55 (4): 1139–43. doi:10.1021/jf062815i. PMID 17253718.
  3. [3]
    Souquet, Jean-Marc; Cheynier, Véronique; Brossaud, Franck; Moutounet, Michel (1996). "Polymeric proanthocyanidins from grape skins". Phytochemistry. 43 (2): 509–512. doi:10.1016/0031-9422(96)00301-9.
  4. [4]
    Saklar, Sena; Ertas, Erdal; Ozdemir, Ibrahim S.; Karadeniz, Bulent (October 2015). "Effects of different brewing conditions on catechin content and sensory acceptance in Turkish green tea infusions". Journal of Food Science and Technology. 52 (10): 6639–6646. doi:10.1007/s13197-015-1746-y. PMC 4573099. PMID 26396411.
  5. [5]
    Katavic PL, Lamb K, Navarro H, Prisinzano TE (August 2007). "Flavonoids as opioid receptor ligands: identification and preliminary structure-activity relationships". J. Nat. Prod. 70 (8): 1278–82. doi:10.1021/np070194x. PMC 2265593. PMID 17685652.

See also


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