Protein argonaute-1 is a protein that in humans is encoded by the EIF2C1 gene.^[5][6][7]

Quick Facts AGO1, Available structures ...

AGO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SI2, 1SI3, 4KRE, 4KRF, 4KXT
Identifiers
Aliases	AGO1, EIF2C, EIF2C1, GERP95, Q99, hAgo1, argonaute 1, RISC catalytic component, argonaute RISC catalytic component 1, argonaute RISC component 1
External IDs	OMIM: 606228; MGI: 2446630; HomoloGene: 81826; GeneCards: AGO1; OMA:AGO1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 35,869,808 bp[1] End 35,930,532 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 126,328,805 bp[2] End 126,362,376 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence visceral pleura parietal pleura hair follicle monocyte internal globus pallidus tibia stromal cell of endometrium middle temporal gyrus parotid gland Top expressed in superior cervical ganglion ganglionic eminence vestibular labyrinth ciliary body otolith organ iris trigeminal ganglion utricle condyle substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II complex binding miRNA binding endoribonuclease activity RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding single-stranded RNA binding RNA binding nucleic acid binding double-stranded RNA binding Cellular component cytoplasm polysome cytosol RISC complex P-body nucleoplasm RISC-loading complex nucleus ribonucleoprotein complex Biological process mRNA destabilization-mediated gene silencing by siRNA regulation of transcription, DNA-templated transcription, DNA-templated pre-miRNA processing nuclear-transcribed mRNA catabolic process positive regulation of gene expression RNA interference miRNA-mediated gene silencing by inhibition of translation RNA secondary structure unwinding mRNA destabilization-mediated gene silencing by miRNA miRNA metabolic process regulation of translation positive regulation of transcription by RNA polymerase II production of miRNAs involved in gene silencing by miRNA positive regulation of NIK/NF-kappaB signaling Wnt signaling pathway, calcium modulating pathway gene silencing regulation of gene silencing by miRNA regulation of megakaryocyte differentiation negative regulation of gene expression negative regulation of angiogenesis RNA phosphodiester bond hydrolysis, endonucleolytic Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26523 236511 Ensembl ENSG00000092847 ENSMUSG00000041530 UniProt Q9UL18 Q8CJG1 RefSeq (mRNA) NM_012199 NM_001317122 NM_001317123 NM_153403 NM_001317173 NM_001317174 NM_001378879 RefSeq (protein) NP_001304051 NP_001304052 NP_036331 NP_001304102 NP_001304103 NP_700452 NP_001365808 Location (UCSC) Chr 1: 35.87 – 35.93 Mb Chr 4: 126.33 – 126.36 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and argonaute 4.^[7]