Dynorphin_B

Dynorphin B

Dynorphin B

Chemical compound

Dynorphin B, also known as rimorphin,[2] is a form of dynorphin and an endogenous opioid peptide with the amino acid sequence Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr. Dynorphin B is generated as a proteolytic cleavage product of leumorphin, which in turn is a cleavage product of preproenkephalin B (prodynorphin).[citation needed]

Quick Facts Names, Identifiers ...


Dynorphin B has an identical N-terminal sequence, but different C-terminal sequence to Dynorphin A. In an alanine scan of the non-glycine residues of dynorphin B, it was discovered that Tyr1 and Phe4 residues are critical for both opioid receptor affinity and κ-opioid receptor agonist potency, Arg6 and Arg7 promote κ-opioid affinity and Lys10 contributes to the opioid receptor affinity.[3]

Inducers of Dynorphin B

Cannabinoid CP55,940 and △9-tetrahydrocannabinol (△9-THC) can induce the release of dynorphin B, which in return acts as an agonist of κ-opioid receptors, resulting in the production of antinociception.[4] Similarly, Tyr-D-Arg-Phe-Sar (TAPS) is capable of promoting a release of dynorphin B through the simulation of μ1-opioid receptors, causing a production of antinociception.[5] The antinociceptive effect produced by dynorphin B allows for spinal analgesia.

See also

References

  1. [1]
    Dynorphin B - Compound Summary, PubChem.
  2. [2]
    Paul V. Malven (12 January 1993). Mammalian Neuroendocrinology. CRC Press. p. 70. ISBN 978-0-8493-8757-9. Retrieved 22 April 2012.
  3. [3]
    Joshi, Anand A.; Murray, Thomas F.; Aldrich, Jane V. (September 2017). "Alanine scan of the opioid peptide dynorphin B amide". Biopolymers. 108 (5): e23026. doi:10.1002/bip.23026. PMC 6003702. PMID 28464209.
  4. [4]
    Houser, Susan J; Eads, Micah; Embrey, James P; Welch, Sandra P (February 2000). "Dynorphin B and spinal analgesia: induction of antinociception by the cannabinoids CP55,940, Δ9-THC and anandamide1Published on the World Wide Web on 18 January 2000.1". Brain Research. 857 (1–2): 337–342. doi:10.1016/S0006-8993(00)01981-8. PMID 10700588. S2CID 8616013.
  5. [5]
    Mizoguchi, Hirokazu; Ito, Kanenori; Watanabe, Hiroyuki; Watanabe, Chizuko; Katsuyama, Sou; Fujimura, Tsutomu; Sakurada, Tsukasa; Sakurada, Shinobu (November 2006). "Contribution of spinal μ1-opioid receptors and dynorphin B to the antinociception induced by Tyr-d-Arg-Phe-Sar". Peptides. 27 (11): 2786–2793. doi:10.1016/j.peptides.2006.07.006. PMID 16919848. S2CID 1770295.



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