Drofenine

Drofenine

Drofenine

Chemical compound

Drofenine is an antimuscarinic antispasmodic drug used for relaxing smooth muscle, thereby treating conditions, such as: dysmenorrhea, and pain in the gastrointestinal tract, biliary passages, and urogenital tract. Drofenine is assumed to work by increasing the levels of the protein TRPV3.[1][2][3]

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References

  1. [1]
    Kunysz EL, Michel AD, Whiting RL (March 1988). "Functional and direct binding studies using subtype selective muscarinic receptor antagonists". British Journal of Pharmacology. 93 (3): 491–500. doi:10.1111/j.1476-5381.1988.tb10303.x. PMC 1853838. PMID 2897216.
  2. [2]
    Bodur E, Cokuğraş AN, Tezcan EF (February 2001). "Inhibition effects of benactyzine and drofenine on human serum butyrylcholinesterase". Archives of Biochemistry and Biophysics. 386 (1): 25–9. doi:10.1006/abbi.2000.2188. PMID 11360997.
  3. [3]
    Deering-Rice CE, Mitchell VK, Romero EG, Abdel Aziz MH, Ryskamp DA, Križaj D, et al. (October 2014). "Drofenine: A 2-APB Analogue with Greater Selectivity for Human TRPV3". Pharmacology Research & Perspectives. 2 (5): e00062. doi:10.1002/prp2.62. PMC 4115637. PMID 25089200.



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