"Do It to It" is the lead single from American girl group Cherish's 2006 debut album, Unappreciated. "Do It to It" features rap/hip hop artist Sean P. The song peaked at number 12 on the Billboard Hot 100 during its 16th week on the chart. It also reached number three on the New Zealand Singles Chart, where it charted for 23 weeks. It had strong video play on BET and reached number two on 106 & Park. The song played for the limit of 65 days on the countdown and was eventually retired. It was the only video to be retired that year that did not reach number one.

The song moves at a tempo of 74 beats per minute in the key of G harmonic minor, and follows the chord progression of G–Cm–Cm–G.

"Do It to It" debuted at number 86 on US Billboard Hot 100 for the week of May 20, 2006.^[1] It peaked at number 12 for the week of September 2, 2006. It stayed on the chart for twenty-one weeks.^[2]

The video begins with the girls' father forbidding them to party, have boys over, or stay up late while their parents are out of town. After he leaves, Farrah turns to the camera and says: "Y'all know it's on, right?". The girls then begin a dance routine in front of a silver background spliced with a wild party being hosted at their house. The next day, the parents return to find the party mess and a boy wandering around the house, leaving the girls sighing at being caught.

The video was shot in Atlanta, Georgia and was directed by Benny Boom.^[3] J-Nicks, Jazze Pha, & D-Roc of the Ying Yang Twins made cameo appearances.

MTV censored the word "kryptonite" from its airings of the video, as in the United States, that word is slang for marijuana.

A remix of the song (Rap Remix) exists, featuring rappers Yung Joc, Jody Breeze, Chingy and Fabo. This version also references some songs by other rappers, such as Yung Joc's "It's Goin' Down" and Fabo from D4L's "Laffy Taffy".

UK CD single^[4]

1. "Do It to It" (main radio version)
2. "He Said She Said" (featuring Nephu)

European CD single^[5]

1. "Do It to It" (main radio version)
2. "That Boi"
3. "Ghetto Mentality"

iTunes EP^[6]

1. "Do It to It" (main radio version) – 3:44
2. "Do It to It" (instrumental) – 3:43
3. "Do It to It" (a cappella) – 3:39

iTunes single^[7]

1. "Do It to It" (main radio version) – 3:44
2. "Do It to It" (edited rap remix) (featuring Jazze Pha, Yung Joc, Jody Breeze, Chingy and Fabo) – 4:10

A tech house^[40] rework by Orlando-based DJ and producer Acraze (Charlie Duncker),^[42] credited to "Acraze featuring Cherish", was released on August 20, 2021.^[43][44] In the United States, it reached number three on the Billboard Hot Dance/Electronic Songs chart,^[45] and in Australia, it reached number 13 on the ARIA Club Tracks chart.^[46] On November 12, the track (as issued by Thrive Music) entered the top 40 of the UK Singles Chart for the first time, arriving at number 36 (up from number 60).^[41] On the Official Charts of January 7, 2022, "Do It to It" reached to UK Top 10 for the first time when it climbed up from number 43 to number nine in its tenth week on the chart^[47] and reached the Irish Top 3.^[48] After dropping as low as number 68 on the UK singles chart,^[49] the song re-entered UK Top 40 (on the chart week-ending March 10, 2022) after the release of the official video.^[50][47]