Dithiobutylamine (DTBA) is a reducing agent intended as an alternative for DTT in biochemical uses. It was designed to be easily synthesized in non-racemic form, to have a lower pKa (allowing more effective reduction at neutral pH), and to have a low disulfide E°′ reduction potential.^[1] It was rationally designed & reported in 2012.^[1] It is commercially available.

This article relies largely or entirely on a single source. (July 2023)

Quick Facts Names, Identifiers ...

Dithiobutylamine^[1]

Names
Preferred IUPAC name (S)-2-aminobutane-1,4-dithiol
Other names DTBA
Identifiers
CAS Number	1363594-47-1(2S) 1363376-98-0 (hydrochloride)
3D model (JSmol)	Interactive image
ChemSpider	32696684
PubChem CID	89734616
InChI InChI=1S/C4H11NS2/c5-4(3-7)1-2-6/h4,6-7H,1-3,5H2/t4-/m0/s1 Key: VGLCUHJZKWYDPC-BYPYZUCNSA-N
SMILES SC[C@H](CCS)N
Properties
Chemical formula	C4H11NS2
Molar mass	137.26 g/mol
Appearance	White solid[1]
Odor	Nearly odorless[1]
Solubility in water	Soluble
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

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