Dipeptidase_E

Dipeptidase E

Dipeptidase E

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Dipeptidase E (EC 3.4.13.21, aspartyl dipeptidase, peptidase E, PepE gene product (Salmonella typhimurium)) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Dipeptidase E catalyses the hydrolysis of dipeptides Asp!Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides
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A free carboxy group is not absolutely required in the substrate.

References

  1. [1]
    Håkansson K, Wang AH, Miller CG (December 2000). "The structure of aspartyl dipeptidase reveals a unique fold with a Ser-His-Glu catalytic triad". Proceedings of the National Academy of Sciences of the United States of America. 97 (26): 14097–102. Bibcode:2000PNAS...9714097H. doi:10.1073/pnas.260376797. PMC 18877. PMID 11106384.
  2. [2]
    Lassy RA, Miller CG (May 2000). "Peptidase E, a peptidase specific for N-terminal aspartic dipeptides, is a serine hydrolase". Journal of Bacteriology. 182 (9): 2536–43. doi:10.1128/jb.182.9.2536-2543.2000. PMC 111318. PMID 10762256.


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