Dimethoxytrityl

Dimethoxytrityl

Dimethoxytrityl

Chemical compound

Dimethoxytrityl, often abbreviated DMT, is a protecting group widely used for protection of the 5'-hydroxy group in nucleosides, particularly in oligonucleotide synthesis.[1]

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It is usually bound to a molecule, but can exist as a stable cation in solution, where it appears bright orange.[2]

References

  1. [1]
    Krotz, Achim; Cole, Douglas; Ravikumar, Vasulinga (1999). "Dimethoxytrityl Removal in Organic Medium: Efficient Oligonucleotide Synthesis Without Chlorinated Solvents". Nucleosides and Nucleotides. 18 (6–7): 1207–1209. doi:10.1080/07328319908044664.
  2. [2]
    "Dimethoxytrityl/DMT (Orange you glad you protected that alcohol?)". Molecule of the Day. 2006-09-05. Retrieved 2022-05-03.
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