Deoxycytidine_triphosphate

Deoxycytidine triphosphate
Names
	IUPAC name 2′-Deoxycytidine 5′-(tetrahydrogen triphosphate)
	Systematic IUPAC name O1-{[(2R,3S,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxyoxolan-2-yl]methyl} tetrahydrogen triphosphate
Identifiers
CAS Number	2056-98-6 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:16311;
ChemSpider	58601 ;
ECHA InfoCard	100.016.504
PubChem CID	65091;
CompTox Dashboard (EPA)	DTXSID60942755 DTXSID50908042, DTXSID60942755 ;
	InChI InChI=1S/C9H16N3O13P3/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(23-8)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H,20,21)(H2,10,11,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 Key: RGWHQCVHVJXOKC-SHYZEUOFSA-N ; InChI=1/C9H16N3O13P3/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(23-8)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H,20,21)(H2,10,11,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 Key: RGWHQCVHVJXOKC-SHYZEUOFBW;
	SMILES C1[C@@H]([C@H](O[C@H]1N2C=CC(=NC2=O)N)CO[P@@](=O)(O)O[P@@](=O)(O)OP(=O)(O)O)O;
Properties
Chemical formula	C9H16N3O13P3
Molar mass	467.156 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Deoxycytidine triphosphate

Chemical compound

Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that contains the pyrimidine base cytosine. The triphosphate group contains high-energy phosphoanhydride bonds, which liberate energy when hydrolized.

Quick Facts Names, Identifiers ...

DNA polymerase enzymes use this energy to incorporate deoxycytidine into a newly synthesized strand of DNA. A chemical equation can be written that represents the process:

(DNA)_n + dCTP ↔ (DNA)_n-C + PP_i

That is, dCTP has the PP_i (pyrophosphate) cleaved off and the dCMP is incorporated into the DNA strand at the 3' end. Subsequent hydrolysis of the PP_i drives the equilibrium of the reaction toward the right side, i.e. incorporation of the nucleotide in the growing DNA chain.

Like other nucleoside triphosphates, manufacturers recommend that dCTP be stored in aqueous solution at −20 °C.^[1]

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This article uses material from the Wikipedia article Deoxycytidine_triphosphate, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.

[1] [1]
"Definitive Guide to dNTPs" (PDF). Retrieved July 29, 2017.

[1]

Deoxycytidine_triphosphate

Deoxycytidine triphosphate

See also

References

External links

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Names


IUPAC name 2′-Deoxycytidine 5′-(tetrahydrogen triphosphate)
Systematic IUPAC name O¹-{[(2R,3S,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxyoxolan-2-yl]methyl} tetrahydrogen triphosphate
Identifiers
CAS Number	2056-98-6^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:16311
ChemSpider	58601^N
ECHA InfoCard	100.016.504
PubChem CID	65091
CompTox Dashboard (EPA)	DTXSID60942755 DTXSID50908042, DTXSID60942755
InChI InChI=1S/C9H16N3O13P3/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(23-8)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H,20,21)(H2,10,11,14)(H2,15,16,17)/t5-,6+,8+/m0/s1^N Key: RGWHQCVHVJXOKC-SHYZEUOFSA-N^N InChI=1/C9H16N3O13P3/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(23-8)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H,20,21)(H2,10,11,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 Key: RGWHQCVHVJXOKC-SHYZEUOFBW
SMILES C1[C@@H]([C@H](O[C@H]1N2C=CC(=NC2=O)N)CO[P@@](=O)(O)O[P@@](=O)(O)OP(=O)(O)O)O
Properties
Chemical formula	C₉H₁₆N₃O₁₃P₃
Molar mass	467.156 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references