Denha I (Syriac: ܕܢܚܐ ܩܕܡܝܐ ܡܦܪܝܢܐ ܕܬܓܪܝܬ, Arabic: دنحا الاول مفريان المشرق)^[1] was the Syriac Orthodox Grand Metropolitan of the East from 649 until his death in 659.^[2] He is commemorated as a saint by the Syriac Orthodox Church in the Martyrology of Rabban Sliba, and his feast day is 2 October.^[3]

Denha became a monk at the monastery of Saint Matthew near Mosul and studied under Marutha, who would later ascend to the office of Grand Metropolitan of the East, the highest-ranking prelate amongst the miaphysite bishops in the former Sasanian Empire.^[4] After Marutha's death on 2 May 649 (AG 960), Denha was chosen to succeed him and was thus brought before the Patriarch Theodore and ordained as archbishop of Tikrit and Grand Metropolitan of the East.^[5] It was formerly asserted by the French orientalist Rubens Duval that Denha was the first miaphysite Grand Metropolitan of the East to hold the title maphrian,^[6] however, it was likely not in use until c. 1100.^[7] He served until his death on 3 November 659 (AG 970) and he was buried with Marutha at the cathedral in the citadel of Tikrit.^[5]

Denha wrote a hagiography of Marutha (Brit. Mus. MS. 14645), which was later translated by the French Syriacist François Nau.^[4]