Deleted_in_lung_and_esophageal_cancer_1

Deleted in lung and esophageal cancer 1

Deleted in lung and esophageal cancer 1

Protein-coding gene in the species Homo sapiens

Deleted in lung and esophageal cancer 1 is a protein that in humans is encoded by the DLEC1 gene. [5]

Quick Facts DLEC1, Identifiers ...

Function

The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016].

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000008226 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000038060 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: Deleted in lung and esophageal cancer 1". Retrieved 2018-04-05.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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