DNA_oxidative_demethylase

DNA oxidative demethylase

DNA oxidative demethylase

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DNA oxidative demethylase (EC 1.14.11.33, alkylated DNA repair protein, alpha-ketoglutarate-dependent dioxygenase ABH1, alkB (gene)) is an enzyme with systematic name methyl DNA-base, 2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming).[1][2][3] This enzyme catalyses the following chemical reaction

DNA-base-CH3 + 2-oxoglutarate + O2 DNA-base + formaldehyde + succinate + CO2
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DNA oxidative demethylase contains iron; activity is somewhat stimulated by ascorbate.

References

  1. [1]
    Falnes PØ, Johansen RF, Seeberg E (September 2002). "AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli". Nature. 419 (6903): 178–82. Bibcode:2002Natur.419..178F. doi:10.1038/nature01048. PMID 12226668. S2CID 2372162.
  2. [2]
    Yi C, Yang CG, He C (April 2009). "A non-heme iron-mediated chemical demethylation in DNA and RNA". Accounts of Chemical Research. 42 (4): 519–29. doi:10.1021/ar800178j. PMC 2920458. PMID 19852088.
  3. [3]
    Yi C, Jia G, Hou G, Dai Q, Zhang W, Zheng G, Jian X, Yang CG, Cui Q, He C (November 2010). "Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase". Nature. 468 (7321): 330–3. Bibcode:2010Natur.468..330Y. doi:10.1038/nature09497. PMC 3058853. PMID 21068844.


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