Cytochrome_p450_family_19_subfamily_a_member_1

Cytochrome p450 family 19 subfamily a member 1

Cytochrome p450 family 19 subfamily a member 1

Protein-coding gene in the species Homo sapiens

Cytochrome P450 family 19 subfamily A member 1 is a protein that in humans is encoded by the CYP19A1 gene. [5]

Quick Facts CYP19A1, Available structures ...

Function

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016].

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000137869 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000032274 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: Cytochrome P450 family 19 subfamily A member 1". Retrieved 2018-06-07.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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