2021: Two-year-old season

Cyberknife began his racing career on 25 September in a Maiden Special Weight event over 6 furlongs at Churchill Downs. Starting as the 6/5 favorite in a field of nine, he began awkwardly, recovering to stalk the leader, then forging ahead three wide while shifting inwards and bumping Hoist the Gold in upper stretch. He dueled that rival while maintaining a narrow margin through the lane and prevailed.^[5] However, after a stewards’ inquiry into the incident in the stretch, Cyberknife was disqualified and placed second.

On 5 November, he returned to the track at Churchill Downs in a Maiden Special Weight event over 6+1⁄2 furlongs. Starting as the 2/5 favorite, Cyberknife tracked the pace early, was in the four path into the lane, made a bid down the lane, drifted out a bit, then lugged in and did not have enough in the final stages to defeat Classic Moment.^[6]

For his third attempt to break his maiden, Cyberknife was moved to the Fair Grounds in New Orleans where he on 26 December broke his maiden over the 1+1⁄16 miles distance, holding off Jeeper by 1⁄2 length.^[7]

2022: Three-year-old season

On 22 January, Cyberknife faced eight rivals in his first run in a graded event, the Grade III Lecomte Stakes at the Fair Grounds. He settled off of the pace four wide, inched closer in the five path and outside of rivals around the far turn to attempt a bid approaching the lane but flattened out in upper stretch to finish sixth, beaten by over 10 lengths.^[8]

On 19 February, Cyberknife dropped in class to an Allowance Optional Claiming event over 1+1⁄16 miles and dispatched his 9 foes as the 9/5 favorite, winning by three lengths.^[9]

In his next start on 2 April, Cyberknife at odds of nearly 6/1 won the Grade I Arkansas Derby at Oaklawn Park by 2+3⁄4 lengths over Barber Road and the filly Secret Oath, securing 100 points for the Kentucky Derby and qualifying for the event.^[4] Trainer Brad Cox commented, "This is a good colt. We've liked him for a long, long, time. I was a little taken back by his Lecomte but he ran very well in the allowance race. He's not polished mentally but he's getting there all the time. The more he races, the better he'll get. He's starting to put it all together."^[4]

In the Kentucky Derby Cyberknife failed to fire, finishing well back in eighteenth place after being fanned eight wide into the first turn.^[10]

One month later, he was entered in the Grade III Matt Winn Stakes and as the 1/2 favorite prevailed by a nose over Howling Time.^[10] Jockey Florent Geroux commented, "He was traveling well and (Howling Time) was really game on my inside. We were battling the whole stretch. I couldn’t tell which one of us won, but I’m glad it was Cyberknife."^[10]

Six weeks later, Cyberknife travelled to the Jersey Shore track of Monmouth Park for the Grade I Haskell Stakes. Facing a field including undefeated Jack Christopher, he was made 8/1 fourth pick in a field of eight.^[11] With a patient ride by regular rider Florent Geroux, he surged to a head victory in a track-record time of 1:46.24 for 1+1⁄8 miles over the Bob Baffert-trained Taiba with Jack Christopher (3/5on) in third place. Al Gold, whose Gold Square owns Cyberknife and who calls Monmouth Park his home away from home, commented, "I have a lot of great memories here, and this is the best horse I've ever had. It's his second grade 1. It's a special feeling. There are no words to describe it."^[3]

The Travers Stakes on 27 August attracted the top three finishers in the Kentucky Derby: (Rich Strike, Epicenter, and Zandon). Other entries included Preakness winner Early Voting and Cyberknife.^[12] Cyberknife started as the 9/2-second favorite and set moderate fractions for the first three-quarters of a mile. Epicenter then began his move on the outside, taking the lead at the quarter-pole. He continued to draw away down the stretch to win by 5+1⁄4 lengths with Cyberknife finishing second, Zandon third, and Rich Strike fourth.^[13]