Cyanoacetamide

Cyanoacetamide

Cyanoacetamide

Chemical compound

2-Cyanoacetamide is an organic compound. It is an acetic amide with a nitrile functional group.

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Uses

Cyanoacetamide is used in spectrofluorimetric methods to determine the activity of antihistamine H1 receptor antagonistic drugs such as ebastine, cetirizine dihydrochloride and fexofenadine hydrochloride.[1]

Preparation

2-Cyanoacetamide is prepared from chloroacetic acid via Kolbe nitrile synthesis[2] followed by Fischer esterification and ester aminolysis.[3]

See also

References

  1. [1]
    Ibrahim, F.; Sharaf El-Din, M. K.; Eid, M.; Wahba, M. E. K. (2011). "Spectrofluorimetric Determination Of Some H1 Receptor Antagonist Drugs In Pharmaceutical Formulations And Biological Fluids". International Journal of Pharmaceutical Sciences and Research. 21 (8): 2056–2072. doi:10.13040/IJPSR.0975-8232.2(8).2056-72.
  2. [2]
    Inglis, J. K. H. (1928). "Ethyl Cyanoacetate". Organic Syntheses. 8: 74. doi:10.15227/orgsyn.008.0074.
  3. [3]
    Corson, B. B.; Scott, R. W.; Vose, C. E. (1941). "Cyanoacetamide". Organic Syntheses. 1: 179. doi:10.15227/orgsyn.009.0036.
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