Cristoforo Spiriti (died 5 November 1556) was a Roman Catholic prelate who served as Titular Patriarch of Jerusalem (1550–1556), and Bishop of Cesena (1510–1550).^[1]

On 8 April 1510, Cristoforo Spiriti was appointed during the papacy of Pope Julius II as Bishop of Cesena.^[1] On 28 February 1550, he was appointed during the papacy of Pope Julius III as Titular Patriarch of Jerusalem.^[1] He served as Patriarch of Jerusalem until his death on 5 November 1556.^[1]

While bishop, he was the principal co-consecrator of:^[1]

• Giovanni Giacomo Barba, Bishop of Teramo (1546);
• Bartolomeo Guidiccioni, Bishop of Teramo (1546); and
• Giulio Canani, Bishop of Adria (1554).