Locus

The human gene CCDC37 is found on chromosome 3 at the band 3q21.3.^[1] It extends from base pairs 90,403,731 to 90,429,231, making the gene 25,500 base pairs long. It is located on the plus strand and contains 17 exons.^{[citation needed]}

Paralogs

There is only one paralog for CCDC37 found in humans, CCDC38. CCDC38 is located on chromosome 12.^[2]

Orthologs

The ortholog space of CCDC37 is fairly broad including mammals, reptiles, birds, amphibians, fish, invertebrates, and fungi.^{[citation needed]}

Primary sequence

The gene encodes a protein called CCDC37. This protein in 611 amino acids in length and has a molecular weight of 71.1 kilodaltons and an isoelectric point of pI=6.7.^{[citation needed]}

Domains

CCDC37 contains a DUF4200 region located from amino acid 151 to 269.^[1] There is no known function for DUF4200. CCDC37 also contains three coiled coil domains at amino acids 164–203, 392–436, and 526–571.^[3]

Post-translational modifications

The protein has several probable post-translational modifications. It contains four possible PEST sequence at amino acids 17–36, 293–304, 337–360, and 360–395.^[4] It also contains a possible substrate of N-acetyltransferase A at Ser₂.^[5]

Signal peptides

CCDC37 has a predicted nuclear localization via Reinhard's method^[6] (reliability 94.1%) using a bipartite nuclear localization signal peptide starting at amino acid 155: KRQMFLLQYALDVKRRE.^[7] CCDC37 also has a few predicted nuclear export signals I232, L235, I239, and M551.^[8]

Transcription factors

There are many predicted transcription factor binding sites in the CCDC37 promoter.^{[citation needed]} Below is a table of the best possibilities, which have high confidence values, evolutionary conservation, and/or multiple possible binding sites in the promoter.

Interactions

There have been three proteins found to interact by physical association with CCDC37 through a yeast two-hybrid screen: histone-lysine N-methyltransferase (SUV39H1), histone-lysine N-methyltransferase (SUV39H2), and lysine-specific histone demethylase 1A (KDM1A).^[13]