Ciclafrine

Ciclafrine

Ciclafrine

Chemical compound

Ciclafrine (INN) is a sympathomimetic phenethylamine and antihypotensive that was never marketed.[1][2] The compound belongs to the class of hemiaminal ethers.

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Synthesis

Ciclafrine can be prepared by the reaction of norfenefrine with cycloheptanone.[3]

Ciclafrine synthesis

References

  1. [1]
    Ganellin CR, Triggle DJ (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 586–. ISBN 978-0-412-46630-4.
  2. [2]
    Korolkovas A (1988). Essentials of medicinal chemistry. John Wiley & Sons, Incorporated. p. 405. ISBN 978-0-471-88356-2.
  3. [3]
    DE 2336746, Satzinger, Gerhard & Herrmann, Manfred, "2-Hydroxyphenyl-1-oxa-4-azaspiro-alkan-Derivate [2-Hydroxyphenyl-1-oxa-4-azaspiro-alkane derivatives]", published 1975-02-13, assigned to Gödecke AG
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