Chisi Island is a small island in the middle of Lake Chilwa. Lake Chilwa is the second largest lake in Malawi. The natives of the island have a wide knowledge of forest and lake usage. There are a few fortified sanctuaries built into the island's hills. Chisi Island is home to Mchenga, a large tree much wider than two humans standing side by side. Chisi Island is sometimes referred to as the most remote location in Malawi.

A BBC reporter visited in 2000 and he found a tribe of people living in houses that float on reed rafts. Two thousand people lived like that and only a small number of them had ever been to the mainland. The two islands they used were Chisi and Thongwe Island. Cholera was endemic. A hospital had been constructed but it had not then been staffed.^[1]