Charles Molesworth Tuke (23 May 1857 – 24 January 1925) was an English surgeon, working in the field of psychiatric care, and first-class cricketer.

He was born in Chiswick, the son of Thomas Harrington Tuke.^[1][2] Educated at St. Paul's School, London, Tuke became a medical student at St George's Hospital. He obtained a surgical diploma in 1881, and began work as a clinical assistant at Bethlem Royal Hospital.^[3] In time he worked at the family-run Manor House Asylum, at Manor Farm House, Chiswick Lane, Chiswick, with his brother Thomas Seymour Tuke (1856–1917).^[2]

After their father's death in 1888, the brothers moved the asylum to leased space at Chiswick House, with a change of name to Chiswick Asylum. They were recorded as tenants there by 1892.^[4] By then, the lease to John Crichton-Stuart, 3rd Marquess of Bute had ended, and artworks belonging to the owner, Victor Cavendish, 9th Duke of Devonshire, had been moved to Chatsworth House.^[5]

Tuke ran Chiswick Asylum alone, in the 1920s.^[6] He died in Chiswick.^[1] His widow resided at Chiswick House until 1929.^[5]

Active as a cricketer 1882–90, Tuke played for Middlesex. He appeared in eight first-class matches.^[1]

Tuke married in 1883 Mary Ella Wylde, second daughter of William Henry Wylde.^[7]