Chanoclavine-I_dehydrogenase

Chanoclavine-I dehydrogenase

Chanoclavine-I dehydrogenase

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Chanoclavine-I dehydrogenase (EC 1.1.1.332, easD (gene), fgaDH (gene)) is an enzyme with systematic name chanoclavine-I:NAD+ oxidoreductase.[1][2] This enzyme catalises the following chemical reaction

chanoclavine-I + NAD+ chanoclavine-I aldehyde + NADH + H+
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This enzyme catalyses a step in the pathway of ergot alkaloid biosynthesis in certain fungi.

References

  1. [1]
    Wallwey C, Matuschek M, Li SM (February 2010). "Ergot alkaloid biosynthesis in Aspergillus fumigatus: conversion of chanoclavine-I to chanoclavine-I aldehyde catalyzed by a short-chain alcohol dehydrogenase FgaDH". Archives of Microbiology. 192 (2): 127–34. doi:10.1007/s00203-009-0536-1. PMID 20039019.
  2. [2]
    Wallwey C, Heddergott C, Xie X, Brakhage AA, Li SM (June 2012). "Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae". Microbiology. 158 (Pt 6): 1634–44. doi:10.1099/mic.0.056796-0. PMID 22403186.
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