The following television stations broadcast on digital channel 21 in the United States:^[1][2][3]

• K21AC-D in Victorville, etc., California, on virtual channel 21
• K21AM-D in Ninilchick, etc., Alaska
• K21BG-D in Jacksonville, Oregon
• K21CA-D in Plains, Montana
• K21CC-D in Lewiston, Idaho
• K21DE-D in Seaside-Astoria, Oregon, on virtual channel 12, which rebroadcasts KPTV
• K21DG-D in St. James, Minnesota
• K21DO-D in Palm Springs, California
• K21EF-D in Pitkin, Colorado, on virtual channel 2
• K21EG-D in Golden Valley, Arizona
• K21EI-D in Beryl/Modena, etc., Utah
• K21EZ-D in Price, Utah
• K21FD-D in Taos, etc., New Mexico
• K21FF-D in Holyoke, Colorado, on virtual channel 7, which rebroadcasts KMGH-TV
• K21FO-D in Winnemucca, Nevada
• K21FS-D in Eugene, Oregon
• K21FT-D in Myton, Utah
• K21FU-D in Topock, Arizona
• K21GE-D in Camp Verde, Arizona
• K21GI-D in Morongo Valley, California, on virtual channel 21
• K21GJ-D in Eureka, Nevada
• K21GN-D in Alexandria, Minnesota, on virtual channel 21
• K21GQ-D in Minot, North Dakota
• K21GT-D in Dove Creek, etc., Colorado, on virtual channel 21
• K21GU-D in Midland, Texas
• K21HH-D in Preston, Idaho, on virtual channel 14, which rebroadcasts KJZZ-TV
• K21HQ-D in Glendo, Wyoming
• K21HV-D in Malad, Idaho
• K21HX-D in Walker, Minnesota, on virtual channel 21, which rebroadcasts WFTC
• K21IA-D in Waipake, Hawaii
• K21IB-D in Circleville, Utah
• K21IC-D in Mount Pleasant, Utah, on virtual channel 5, which rebroadcasts KSL-TV
• K21IL-D in Apple Valley, Utah
• K21IM-D in Fort Sumner, New Mexico
• K21IN-D in Ridgecrest, etc., California, on virtual channel 9, which rebroadcasts KCAL-TV
• K21IR-D in Childress, Texas
• K21IT-D in Weatherford, Oklahoma
• K21IU-D in Navajo Mtn. Sch., etc., Utah
• K21IV-D in Oljeto, Utah
• K21IW-D in Mexican Hat, Utah
• K21IX-D in Montezuma Creek/Aneth, Utah
• K21JC-D in Pocatello, Idaho
• K21JI-D in Cave Junction, etc., Oregon
• K21JK-D in Montrose, Colorado
• K21JN-D in Erick, Oklahoma
• K21JQ-D in Walla Walla, Washington
• K21JS-D in Harrison, Arkansas
• K21JU-D in Meeteetse, Wyoming
• K21JV-D in Green River, Utah
• K21JX-D in Huntington, Utah
• K21JZ-D in Nephi, Utah, on virtual channel 4, which rebroadcasts KTVX
• K21KA-D in Ferndale, Montana
• K21KB-D in Brookings, Oregon
• K21KC-D in Bluff, etc., Utah
• K21KE-D in Canyonville, Oregon
• K21KF-D in Frost, Minnesota
• K21KI-D in Hatch, Utah
• K21KL-D in Rural Beaver County, Utah
• K21KY-D in Bigfork/Marcell, Minnesota
• K21LB-D in Lincoln City, Oregon
• K21LC-D in Cortez, Colorado
• K21LD-D in Mazama, Washington
• K21LI-D in Idaho Falls, Idaho
• K21LR-D in Alamogordo, New Mexico
• K21LW-D in Gazelle, California
• K21LY-D in Mapleton, Oregon
• K21MA-D in Emigrant, Montana
• K21MB-D in Scottsburg, Oregon
• K21MH-D in Daggett, California, on virtual channel 21
• K21MO-D in Riverside, California
• K21MP-D in Lawton, Oklahoma
• K21MR-D in Soda Springs, Idaho
• K21MS-D in La Grande, Oregon
• K21MT-D in Seiling, Oklahoma
• K21MU-D in Summit County, Utah
• K21MV-D in Farmington, New Mexico
• K21MW-D in Thompson Falls, Montana
• K21MX-D in Garfield, etc., Utah
• K21MY-D in Richfield, etc., Utah, on virtual channel 14, which rebroadcasts KJZZ-TV
• K21MZ-D in Koosharem, Utah
• K21NA-D in Bicknell & Teasdale, Utah
• K21NB-D in Rural Sevier County, Utah
• K21NC-D in Henrieville, Utah
• K21ND-D in Mayfield, Utah
• K21NE-D in Panguitch, Utah
• K21NF-D in Roseau, Minnesota
• K21NG-D in Sandpoint, Idaho
• K21NH-D in Laketown, etc., Utah, on virtual channel 9, which rebroadcasts KUEN
• K21NI-D in Wendover, Utah
• K21NK-D in Cedar City, Utah, on virtual channel 30, which rebroadcasts KUCW
• K21NN-D in Scipio/Holden, Utah
• K21NO-D in Leamington, Utah
• K21NP-D in Orangeville, Utah, on virtual channel 13, which rebroadcasts KSTU
• K21NQ-D in Meadview, Arizona
• K21NS-D in Olivia, Minnesota
• K21NW-D in Tulia, Texas
• K21NZ-D in Anton, Colorado, on virtual channel 47
• K21OA-D in Holbrook, Idaho
• K21OB-D in Lake Charles, Louisiana
• K21OC-D in Corpus Christi, Texas
• K21OD-D in Many Farms, Arizona
• K21OF-D in Tucumcari, New Mexico
• K21OG-D in Bayfield, Colorado
• K21OH-D in Datil/Horse Springs, New Mexico
• K21OI-D in Mccook/Culbertson, Nebraska
• K21OJ-D in Ruth, Nevada
• K21OK-D in Lund & Preston, Nevada
• K21OM-D in Lafayette, Louisiana
• K21OO-D in South Eureka/Loleta, California
• K21OS-D in Beowawe, Nevada
• K21OT-D in Pasco-Kennewick, Washington
• K21OV-D in Redstone, Colorado
• K21OW-D in Lordsburg, New Mexico
• K21OY-D in Chico, California
• K21OZ-D in Shreveport, Louisiana
• K21PD-D in Columbia, Missouri
• K21PE-D in Tyler, Texas
• K21PI-D in Monterey, California
• K36KN-D in Eureka, Nevada
• KAID in Boise, Idaho
• KAJR-LD in Des Moines, Iowa
• KAKE in Wichita, Kansas
• KANG-LD in San Angelo, Texas, uses KEUS-LD's spectrum
• KCIB-LD in El Dorado, Arkansas
• KCNZ-CD in San Francisco, California, on virtual channel 28
• KDCK in Dodge City, Kansas
• KDEO-LD in Denver, Colorado, on virtual channel 23
• KDLT-TV in Sioux Falls, South Dakota
• KDTV-CD in Santa Rosa, California, on virtual channel 28
• KDTX-TV in Dallas, Texas, on virtual channel 58
• KEJT-CD in Salt Lake City, Utah, on virtual channel 50, which rebroadcasts KTMW
• KEUS-LD in San Angelo, Texas
• KFCT in Fort Collins, Colorado, on virtual channel 22
• KFTV-DT in Hanford, California
• KGCS-LD in Joplin, Missouri
• KGCW in Burlington, Iowa
• KGHB-CD in Pueblo, etc., Colorado
• KGRF-LD in Gila River Indian Community, Arizona, on virtual channel 29, which rebroadcasts KGRQ-LD
• KGRQ-LD in Gila River Indian Community, Arizona, on virtual channel 29
• KHBB-LD in Helena, Montana
• KHBS in Fort Smith, Arkansas
• KHTX-LD in Huntsville, Texas, to move to channel 29, on virtual channel 30
• KKRP-LD in St. George, Utah, on virtual channel 13, which rebroadcasts KSTU
• KKSU-LD in Manhattan, Kansas
• KKTM-LD in Altus, Oklahoma
• KKYK-CD in Little Rock, Arkansas
• KLEI in Wailuku, Hawaii
• KLSV-LD in Las Vegas, Nevada
• KLUJ-TV in Harlingen, Texas
• KMLF-LD in Grand Island, Nebraska
• KMTP-TV in San Francisco, California, uses KCNZ-CD's spectrum, to move to channel 32 and to use KCNS' spectrum, on virtual channel 32
• KNBN in Rapid City, South Dakota
• KOFY-TV in San Francisco, California, uses KCNZ-CD's spectrum, on virtual channel 20
• KPMR in Santa Barbara, California
• KPXG-LD in Portland, Oregon, on virtual channel 42
• KQMK-LD in Lincoln, Nebraska
• KQRM-LD in Petaluma, California, uses KCNZ-CD's spectrum, on virtual channel 18
• KRFT-LD in Springfield, Missouri
• KRVU-LD in Redding, California
• KRWB-TV in Roswell, New Mexico
• KRXI-TV in Reno, Nevada
• KSCE in El Paso, Texas
• KSPX-TV in Sacramento, California, on virtual channel 29
• KTAJ-TV in St. Joseph, Missouri, on virtual channel 16
• KTAV-LD in Los Angeles, California, on virtual channel 35
• KTBW-TV in Tacoma, Washington, on virtual channel 20
• KTVZ in Bend, Oregon
• KUGF-TV in Great Falls, Montana
• KUOT-CD in Oklahoma City, Oklahoma
• KWBA-TV in Sierra Vista, Arizona
• KXAB-LD in Abilene, Texas
• KXAN-TV in Austin, Texas
• KYNM-CD in Albuquerque, New Mexico
• KYVE in Yakima, Washington
• KZJL in Houston, Texas, on virtual channel 61
• W21AU-D in Orlando, Florida, on virtual channel 21
• W21CP-D in Gloversville, New York
• W21CX-D in Mayaguez, Puerto Rico, on virtual channel 12, which rebroadcasts WOLE-DT
• W21DS-D in Sayner/Vilas County, Wisconsin
• W21DV-D in Bryson City, North Carolina
• W21DZ-D in Romney, West Virginia
• W21EA-D in Parkersburg, West Virginia
• W21EF-D in Waupaca, Wisconsin, on virtual channel 8
• W21EK-D in Key West, Florida
• W21EL-D in Valdosta, Georgia
• W21EO-D in Orono, Maine
• WABE-TV in Atlanta, Georgia
• WAPT in Jackson, Mississippi
• WAUT-LD in Auburn, Alabama
• WBNS-TV in Columbus, Ohio, on virtual channel 10
• WBRL-CD in Baton Rouge, Louisiana
• WCLF in Clearwater, Florida, on virtual channel 22
• WDAY-TV in Fargo, North Dakota
• WDHN in Dothan, Alabama
• WDRF-LD in Augusta, Georgia
• WDYB-CD in Daytona Beach, Florida, on virtual channel 14
• WEAE-LD in Springfield, Illinois
• WEBA-TV in Allendale, South Carolina
• WEDW in Stamford, Connecticut, on virtual channel 49
• WEEV-LD in Evansville, Indiana
• WEFG-LD in Philadelphia, Pennsylvania, on virtual channel 7
• WETU-LD in Montgomery, Alabama
• WEUX in Chippewa Falls, Wisconsin
• WFUP in Vanderbilt, Michigan
• WFXQ-CD in Springfield, Massachusetts, an ATSC 3.0 station
• WFYI in Indianapolis, Indiana, on virtual channel 20
• WGPS-LD in Fort Myers, Florida
• WHLZ-LD in Harrisburg, Pennsylvania
• WHNO in New Orleans, Louisiana
• WHWV-LD in Huntington, West Virginia
• WJEB-TV in Jacksonville, Florida
• WJKT in Jackson, Tennessee
• WJPX in San Juan, Puerto Rico, on virtual channel 24
• WJYS in Hammond, Indiana, on virtual channel 62
• WKME-CD in Kissimmee, Florida, on virtual channel 31, which rebroadcasts WTMO-CD
• WKMG-LD in Ocala, Florida
• WKYT-TV in Lexington, Kentucky
• WMPT in Annapolis, Maryland, on virtual channel 22
• WNCR-LD in Tarboro, North Carolina, on virtual channel 41
• WNEP-TV in Scranton, Pennsylvania
• WPAN in Fort Walton Beach, Florida
• WPNT in Pittsburgh, Pennsylvania, an ATSC 3.0 station, on virtual channel 22
• WPXM-TV in Miami, Florida, on virtual channel 35
• WQDI-LD in Canton, Ohio, on virtual channel 20
• WRLW-CD in Salem, Indiana
• WROC-TV in Rochester, New York
• WSBK-TV in Boston, Massachusetts, on virtual channel 38
• WSEE-TV in Erie, Pennsylvania
• WSLF-LD in Port St. Lucie, Florida
• WTCV in San Juan, Puerto Rico, uses WJPX's spectrum, on virtual channel 18
• WTMH-LD in Macon, Georgia
• WTTO in Homewood, Alabama
• WUMN-LD in Minneapolis, Minnesota, on virtual channel 21
• WUNG-TV in Concord, North Carolina, on virtual channel 58
• WUXP-TV in Nashville, Tennessee, an ATSC 3.0 station, on virtual channel 30
• WVBT in Virginia Beach, Virginia
• WVDM-LD in Quincy, Illinois
• WVIA-TV in Scranton, Pennsylvania, uses WNEP-TV's spectrum
• WWCW in Lynchburg, Virginia
• WWIW-LD in Raleigh, North Carolina, on virtual channel 66
• WWJ-TV in Detroit, Michigan, on virtual channel 62
• WZME in Bridgeport, Connecticut, uses WEDW's spectrum, on virtual channel 43
• WZPX-TV in Battle Creek, Michigan
• WZVI in Charlotte Amalie, U.S. Virgin Islands

The following stations, which are no longer licensed, formerly broadcast on digital channel 21 in the United States:

• K21CD-D in Ukiah, California
• K21EA-D in Lake Havasu City, Arizona
• K21HF-D in Aspen, Colorado
• K21KD-D in Wyola, Montana
• K21LV-D in Perryton, Texas
• K21MC-D in Hobbs, New Mexico
• K21NJ-D in Three Forks, Montana
• K21NL-D in Howard, Montana
• K21NX-D in Hermiston, Washington
• K21PC-D in Geronimo, Oklahoma
• KDKW-LD in Lubbock, Texas
• KDUG-LD in Hemet, California
• KGRY-LD in Gila River Indian Community, Arizona
• KMIK-LD in Cedar Falls, Iowa
• KRPO-LD in Quartzsite, Arizona
• KWDA-LD in Dallas, Texas
• W21CL-D in Marathon, Florida
• W21DA-D in Dublin, Georgia
• W21DD-D in Naguabo, Puerto Rico
• W21EB-D in Clarksburg, West Virginia
• WDLP-CD in Pompano Beach, Florida