Caveolin_2

Caveolin 2

Caveolin 2

Mammalian protein found in Homo sapiens

Caveolin-2 is a protein that in humans is encoded by the CAV2 gene.[5][6][7]

Not to be confused with 2CAV, the 2nd Cavalry (disambiguation)
For the ICAO coded Hope (Fraser Canyon Hospital) Heliport, see Hope, British Columbia.
Quick Facts CAV2, Identifiers ...

The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. The CAV1 and CAV2 genes are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex,[7][8] which can be disrupted by Src-mediated phosphorylation of tyrosine 19 on caveolin-2.[9] Two transcript variants encoding distinct isoforms have been identified for this gene. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by one transcript.[7]

Interactions

Caveolin 2 has been shown to interact with Caveolin 1[8][10] and RAS p21 protein activator 1.[9]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000105971 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000000058 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Scherer PE, Okamoto T, Chun M, Nishimoto I, Lodish HF, Lisanti MP (Feb 1996). "Identification, sequence, and expression of caveolin-2 defines a caveolin gene family". Proc Natl Acad Sci U S A. 93 (1): 131–5. Bibcode:1996PNAS...93..131S. doi:10.1073/pnas.93.1.131. PMC 40192. PMID 8552590.
  6. [6]
    Fra AM, Mastroianni N, Mancini M, Pasqualetto E, Sitia R (May 1999). "Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors". Genomics. 56 (3): 355–6. doi:10.1006/geno.1998.5723. PMID 10087206.
  7. [7]
    "Entrez Gene: CAV2 caveolin 2".
  8. [8]
    Scherer PE, Lewis R Y, Volonte D, Engelman J A, Galbiati F, Couet J, Kohtz D S, van Donselaar E, Peters P, Lisanti M P (Nov 1997). "Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo". J. Biol. Chem. 272 (46). UNITED STATES: 29337–46. doi:10.1074/jbc.272.46.29337. ISSN 0021-9258. PMID 9361015.
  9. [9]
    Lee H, Park David S, Wang Xiao Bo, Scherer Philipp E, Schwartz Phillip E, Lisanti Michael P (Sep 2002). "Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1". J. Biol. Chem. 277 (37). United States: 34556–67. doi:10.1074/jbc.M204367200. ISSN 0021-9258. PMID 12091389.
  10. [10]
    Breuza L, Corby Séverine, Arsanto Jean-Pierre, Delgrossi Marie-Hélène, Scheiffele Peter, Le Bivic André (Dec 2002). "The scaffolding domain of caveolin 2 is responsible for its Golgi localization in Caco-2 cells". J. Cell Sci. 115 (Pt 23). England: 4457–67. doi:10.1242/jcs.00130. ISSN 0021-9533. PMID 12414992. S2CID 14788127.

Further reading


Stub icon

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article Caveolin_2, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.