Caltanissetta Cathedral (Italian: Cattedrale di Caltanissetta; Chiesa di Santa Maria la Nova) is the cathedral of the Roman Catholic Diocese of Caltanissetta. It is located in Caltanissetta, Sicily, Italy.

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Its construction began in 1570 and ended in 1622.^[1] Between 1718 and 1720 the Flemish painter Guglielmo Borremans, together with his son Luigi, frescoed the vault and the nave, and painted the greater altarpiece, depicting the Immaculate Conception.^[1]

• Catholic Church in Italy