CYREN_(protein)

CYREN (protein)

CYREN (protein)

Protein-coding gene in the species Homo sapiens

Cell cycle regulator of non-homologous end joining is a protein that in humans is encoded by the CYREN gene.

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It prevents classical non-homologous end joining, a method of repair of double-stranded DNA breaks.[5] This protein is therefore important in regulating DNA repair.

When alternatively spliced, is predicted to produce three different micropeptides.[6]

  • MRI-1 was previously found to be a modulator of retrovirus infection.[6]
  • MRI-2 may be important in non-homologous end joining (NHEJ) of DNA double strand breaks. In Co-Immunoprecipitation experiments, MRI-2 bound to Ku70 and Ku80, two subunits of Ku, which play a major role in the NHEJ pathway.[6]
  • MRI-3

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000122783 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000046806 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Arnoult N, Correia A, Ma J, Merlo A, Garcia-Gomez S, Maric M, Tognetti M, Benner CW, Boulton SJ, Saghatelian A, Karlseder J (September 2017). "Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN". Nature. 549 (7673): 548–552. Bibcode:2017Natur.549..548A. doi:10.1038/nature24023. PMC 5624508. PMID 28959974.
  6. [6]
    Slavoff SA, Heo J, Budnik BA, Hanakahi LA, Saghatelian A (April 2014). "A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining". The Journal of Biological Chemistry. 289 (16): 10950–7. doi:10.1074/jbc.c113.533968. PMC 4036235. PMID 24610814.
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