CLCA3
CLCA3
Pseudogene in the species Homo sapiens
Chloride channel accessory 3, also known as CLCA3, is a protein which in humans is encoded by the CLCA3P pseudogene. The protein encoded by this gene is a chloride channel.[3] According to the HGNC, this protein is not expressed in humans but is in certain other species such as mouse. However, some conflicting reports state that human cells produce and glycosylate this protein.[3]
| CLCA3P | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | CLCA3P, CLCA3, chloride channel accessory 3, pseudogene | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 604337 GeneCards: CLCA3P | ||||||||||||||||||||||||||||||||||||||||||||||||||
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This gene is a transcribed pseudogene belonging to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. This gene contains several nonsense codons compared to other family members that render the transcript a candidate for nonsense-mediated mRNA decay (NMD), although this gene is translated into a well characterized protein which has been shown to decorate mucin granule containing vesicles. Protein structure prediction methods suggest the N-terminal region of CLCA3 protein is a zinc metalloprotease, and the protein is not an ion channel per se.[4]
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Gruber AD, Pauli BU (March 1999). "Molecular cloning and biochemical characterization of a truncated, secreted member of the human family of Ca2+-activated Cl- channels". Biochimica et Biophysica Acta. 1444 (3): 418–23. doi:10.1016/S0167-4781(99)00008-1. PMID 10095065.
- Liu QH, Williams DA, McManus C, Baribaud F, Doms RW, Schols D, et al. (April 2000). "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proceedings of the National Academy of Sciences of the United States of America. 97 (9): 4832–7. Bibcode:2000PNAS...97.4832L. doi:10.1073/pnas.090521697. PMC 18318. PMID 10758170.
- Pauli BU, Abdel-Ghany M, Cheng HC, Gruber AD, Archibald HA, Elble RC (November 2000). "Molecular characteristics and functional diversity of CLCA family members". Clinical and Experimental Pharmacology & Physiology. 27 (11): 901–5. doi:10.1046/j.1440-1681.2000.03358.x. PMID 11071307. S2CID 28762005.
- Gruber AD, Pauli BU (October 1999). "Clustering of the human CLCA gene family on the short arm of chromosome 1 (1p22-31)". Genome. 42 (5): 1030–2. doi:10.1139/gen-42-5-1030. PMID 10584316.
- CLCA3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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