Choriogonadotropin subunit beta variant 1 is a protein that in humans is encoded by the CGB1 gene.^[3][4]

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CGB1
Identifiers
Aliases	CGB1, chorionic gonadotropin beta subunit 1, chorionic gonadotropin subunit beta 1
External IDs	OMIM: 608823 HomoloGene: 137643 GeneCards: CGB1
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 49,035,569 bp[1] End 49,036,895 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas duodenum stromal cell of endometrium right uterine tube fundus pituitary gland body of stomach renal cortex anterior pituitary smooth muscle tissue n/a More reference expression data BioGPS n/a
Gene ontology Molecular function hormone activity Cellular component extracellular region extracellular space cytoplasm Biological process G protein-coupled receptor signaling pathway cell-cell signaling hormone-mediated signaling pathway ovulation regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114335 n/a Ensembl ENSG00000267631 n/a UniProt A6NKQ9 n/a RefSeq (mRNA) NM_033377 NM_001382421 n/a RefSeq (protein) NP_203695 NP_001369350 n/a Location (UCSC) Chr 19: 49.04 – 49.04 Mb n/a PubMed search [2] n/a
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The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranslated region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB1 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (Dirnhofer S, Hermann M, Hittmair A, Hoermann R, Kapelari K, Berger P (December 1996). "Expression of the human chorionic gonadotropin-beta gene cluster in human pituitaries and alternate use of exon 1". J. Clin. Endocrinol. Metab. 81 (12): 4212–7. doi:10.1210/jcem.81.12.8954017. PMID 8954017.). However, a 155 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits.^[4]