CD3G
CD3G
Protein-coding gene in the species Homo sapiens
T-cell surface glycoprotein CD3 gamma chain is a protein that in humans is encoded by the CD3G gene.
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T cell antigen receptor (TCR) is associated on the T cell surface with a complex of protein called CD3. CD3G (gamma chain) is one of the four peptides (gamma, delta, epsilon and zeta) that form CD3. Defects in CD3G are associated with T cell immunodeficiency.[5]
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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- Griesinger F, Greenberg JM, Kersey JH (1989). "T cell receptor gamma and delta rearrangements in hematologic malignancies. Relationship to lymphoid differentiation". J. Clin. Invest. 84 (2): 506–16. doi:10.1172/JCI114193. PMC 548910. PMID 2547833.
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- Davies AA, Cantrell DA, Hexham JM, et al. (1987). "The human T3 gamma chain is phosphorylated at serine 126 in response to T lymphocyte activation". J. Biol. Chem. 262 (23): 10918–21. doi:10.1016/S0021-9258(18)60903-2. PMID 3112151.
- Gold DP, Clevers H, Alarcon B, et al. (1987). "Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family". Proc. Natl. Acad. Sci. U.S.A. 84 (21): 7649–53. Bibcode:1987PNAS...84.7649G. doi:10.1073/pnas.84.21.7649. PMC 299357. PMID 3478717.
- Oravecz T, Norcross MA (1994). "Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120". AIDS Res. Hum. Retroviruses. 9 (10): 945–55. doi:10.1089/aid.1993.9.945. PMID 7506554.
- Human CD3G genome location and CD3G gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: P09693 (T-cell surface glycoprotein CD3 gamma chain) at the PDBe-KB.
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