In the United States Government, the Bureau of European and Eurasian Affairs (EUR) is part of the United States Department of State, charged with implementing U.S. foreign policy and promoting U.S. interests in Europe and Eurasia (which it defines as being Europe, Turkey, Cyprus, the Caucasus Region, and Russia), as well as advising the Under Secretary of State for Political Affairs. It is headed by the Assistant Secretary of State for European and Eurasian Affairs.

From 1949 to 1983, European affairs were within the purview of the Bureau of European Affairs.

The offices of the Bureau of European and Eurasian Affairs direct, coordinate, and supervise U.S. government activities within the region, including political, economic, consular, public diplomacy, and administrative management issues.^[2][3]

• Front Office
• Joint Executive Office – Oversees the bureau's human resources; shared with the Bureau of International Organization Affairs
• Office of the Coordinator for U.S. Assistance to Europe and Eurasia – Coordinates policy regarding the European Union, the European Commission, the European Council, the European Parliament, and the Council of Europe
• Office of the Special Envoy for Holocaust Issues
• Office of European Union and Regional Affairs
• Office of Caucasus Affairs and Regional Conflicts – Responsible for Armenia, Azerbaijan, and Georgia, and supports the U.S. Co-Chair of the OSCE Minsk Group
• Office of Central European Affairs – Responsible for Austria, Bulgaria, the Czech Republic, Hungary, Liechtenstein, Poland, Romania, Slovakia, Slovenia, and Switzerland
• Office of Nordic and Baltic Affairs – Responsible for Denmark, Estonia, Finland, Iceland, Latvia, Lithuania, Norway, and Sweden
• Office of Policy and Global Issues – Responsible for policy formulation and substantive expertise about global issues within the EUR region; strategic planning; and Congressional relations
• Office of Press and Policy Outreach – Coordinates media engagement and public outreach, and prepares press guidance for the Department Spokesperson in the Bureau of Public Affairs
• Office of Public Diplomacy – Coordinates public diplomacy strategies at U.S. posts in the EUR region
• Office of Policy and Regional Affairs – Coordinates policy on nonproliferation and security issues, nuclear and strategic issues, missile defense, arms control, security assistance, sanctions, Cooperative Threat Reduction (CTR) policy and implementation, and international space cooperation
• Office of Regional Security and Political Military Affairs – Coordinates policy on U.S. security interests, as well as policy regarding NATO, the Organization for Security and Co-operation in Europe, and European contributions to multinational military operations
• Office of Russian Affairs – Responsible for Russia. Formerly the Office of Soviet Union Affairs - Responsible for the Soviet Union
• Office of South Central European Affairs – Responsible for Albania, Bosnia-Herzegovina, Croatia, Kosovo, Montenegro, North Macedonia and Serbia
• Office of Southern European Affairs – Responsible for Cyprus, Greece, and Turkey
• Office of Eastern European Affairs – Responsible for Belarus, Moldova, and Ukraine
• Office of Western European Affairs – Responsible for Andorra, Belgium, France, Germany, the Holy See/Vatican City, Ireland, Italy, Luxembourg, Malta, Monaco, the Netherlands, Portugal, San Marino, Spain and the United Kingdom