Brigitte Sy (born 26 January 1956) is a French actress and filmmaker. Her directorial film debut, Les Mains libres, was released in 2010 to critical acclaim in France.^[1][2][3]

She is the mother of the actors Louis Garrel and Esther Garrel whom she had with the director Philippe Garrel.^[4] In an Arte short film collection about AIDS awareness, she revealed that she has been HIV-positive since 1990, contracted from a partner who previously had a drug addiction.^[5] She also addresses the issue in Les mains libres and L'endroit idéal where the protagonist, Barbara (played by Ronit Elkabetz), is HIV-positive.^[6] Along with 99 other French women writers, performers and academics, she signed an open letter that argued the #Me Too movement had gone too far, turning into a "witch hunt", and denounced it as a form of puritanism, resulting in a backlash.^[7][8][9]

She is of Sephardic Jewish descent.^[10][11]