Bone_morphogenetic_protein_8B

Bone morphogenetic protein 8B

Bone morphogenetic protein 8B

Protein-coding gene in the species Homo sapiens

Bone morphogenetic protein 8B is a protein that in humans is encoded by the BMP8B gene.[5][6][7]

Quick Facts BMP8B, Identifiers ...

The protein encoded by this gene is a member of the TGF-β superfamily. It has close sequence homology to BMP7 and BMP5 and is believed to play a role in bone and cartilage development. It has been shown to be expressed in the hippocampus of murine embryos.

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity.[7]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000116985 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000032726 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Ozkaynak E, Schnegelsberg PN, Jin DF, Clifford GM, Warren FD, Drier EA, Oppermann H (Jan 1993). "Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis". J Biol Chem. 267 (35): 25220–7. doi:10.1016/S0021-9258(19)74028-9. PMID 1460021.
  6. [6]
    DiLeone RJ, King JA, Storm EE, Copeland NG, Jenkins NA, Kingsley DM (Jun 1997). "The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4". Genomics. 40 (1): 196–8. doi:10.1006/geno.1996.4533. PMID 9070944.
  7. [7]
    "Entrez Gene: BMP8B bone morphogenetic protein 8b (osteogenic protein 2)".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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