Benzylthiouracil

Benzylthiouracil

Benzylthiouracil

Chemical compound

Benzylthiouracil (BTU) is an antithyroid preparation. It is a thioamide, closely related to propylthiouracil.

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Adverse effects

Benzylthiouracil has been associated with severe adverse effects, notably vasculitis and subsequent ANCA-positive glomerulonephritis, as well as isolated reports of lung damage.[1][2][3][4]

References

  1. [1]
    Tieulie N, Huong DL, Andreu M, et al. (2002). "[ANCA associated glomerulonephritis related to benzylthiouracil]". Rev Méd Interne (in French). 23 (10): 853–6. doi:10.1016/S0248-8663(02)00694-X. PMID 12428489.
  2. [2]
    Kaaroud H, Khiari K, Ben Moussa F, Barbouch S, Boussema E, Ben Maïz H (2002). "[Vasculitis with renal and pulmonary involvement in a patient receiving benzylthiouracil for Graves disease]". Rev Méd Interne (in French). 23 (10): 857–61. doi:10.1016/S0248-8663(02)00704-X. PMID 12428490.
  3. [3]
    Braham A, Houman MH, Rais L, Ben Gborbel I, Lamloum M, Miled M (2004). "[Benzylthiouracil induced ANCA-positive vasculitis]". Presse Médicale (in French). 33 (19 Pt 1): 1331–3. doi:10.1016/S0755-4982(04)98919-1. PMID 15615240.
  4. [4]
    Thabet F, Sghiri R, Tabarki B, Ghedira I, Yacoub M, Essoussi AS (2006). "ANCA-associated diffuse alveolar hemorrhage due to benzylthiouracil". Eur J Pediatr. 165 (7): 435–6. doi:10.1007/s00431-005-0053-4. PMID 16622664.


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