Barnidipine

Barnidipine

Barnidipine

Antihypertensive drug of the calcium channel blocker class

Barnidipine (INN; also known as mepirodipine) is a calcium channel blocker which belongs to the dihydropyridine (DHP) group of calcium channel blockers. It is used in the treatment of hypertension.[1]

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Pharmacodynamics

Barnidipine is a pure S,S isomer, a lipophilic 1,4-dihydropyridine calcium channel blocker, which, like other compounds in the class, shows a high affinity for calcium channels, particularly the L-type slow channels of smooth muscle cells found in the vessel wall.[2] Calcium channel blocking drugs have the characteristic of interfering with the flow of calcium ions into the interior of cells through the slow channels of the plasma membrane.

References

  1. [1]
    CID 443869 from PubChem
  2. [2]
    van Zwieten, PA. (1998). "Pharmacological profile of barnidipine: a single optical isomer dihydropyridine calcium antagonist". Blood Press Suppl. 1: 5–8. PMID 9660520.
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