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• Darryl MacPherson (Mike O'Malley) is the uptight and responsible father of Zoe and husband to Wanda. He tends to think Wanda's heart-felt ideas are crazy, but will later agree with them if there is an advantage for himself. He wants the best for his baby daughter, but can overly protect her. Despite intending to do the right thing, he has done unexpected selfish things, such as pretending to grieve over going with Carl and their kids to a fun zone, only to watch an attractive dancer at the place singing every time it was a child's birthday. But in the end, he is faithful to his wife and daughter. Darryl often feels that his wife nags him and will always discuss his issues to his friend, Kenny at work. Most commonly, he will talk about a problem, the next day, talk about how happy he is to have solved the problem an easy way, then the next day, talk about how it did not work out. Darryl is quick to express jealousy—particularly of Carl, his next door neighbor.
• Wanda MacPherson (Julia Sweeney) is Darryl's wife and Zoe's mother. She is caring, unpredictable, passionate and impulsive by turns. However, just as Darryl does, she loves Zoe and wants only the best for her. Wanda is a stay at home mom. Her closest friends are her neighbor Melinda and a teenage girl named Bizzy, who serves as Zoe's babysitter from time to time. Wanda generally has a cheerful disposition, but she is quick to let her emotions get the best of her. She will usually go through drastic measures to fix something, against her husband's wishes. Wanda is occasionally melancholy about motherhood, as suggested by the title Baby Blues. She is said to have a "crazy spark" in her that never left. This is seen at one point, when she wants to feel young again and escapes with Bizzy and her friends at night and gets caught by the police. Wanda's unpredictable and impulsive behavior is often a source of extreme stress for Darryl. However, in the end, they always settle their differences and make peace after the arguments and problems are resolved.
• Zoe MacPherson (E. G. Daily) is the infant daughter of Darryl and Wanda. As a baby, Zoe's curiosity and emotions are expressed in her eyes, which show almost complete understanding when something happens or if somebody talks to her. Although calm and cheerful in the day time, she is very loud and cries nonstop at night, leaving her parents to stay up all night, taking turns rocking her, and carrying her until day time. Zoe appears to have a really close relationship with Rodney, the trouble kid next door who seems to be the only one who could stop her crying and comfort her.
• Melinda Bitterman (Arabella Field) is Wanda's friend and neighbor whose family is dysfunctional. Melinda is always seen smoking in her yard as her husband and kids are working on some bizarre, dangerous or disastrous activity. Any time she sees Wanda, she always greets with the same line, "Hi Wanda, how's the baby?" Seemingly careless or tired, Melinda seems to desire the happiness and relationship she once had before she became a mother and somewhat envies Wanda's stable life, but is still content with her family. She always talks in a calm voice, even when discussing an insane thing that her family is doing, as if it were normal.
• Carl Bitterman (Joel Murray) is Melinda's husky, big-muscled and overweight husband. A seemingly bum like man, Carl claims that he gives his kids strict discipline, even though he has lowered himself to their level many times, particularly Rodney, who pesters Carl until he takes aggressive action. Carl is usually envied by Darryl, for his mechanic skills and other things Darryl fails at. Carl can be rude and obnoxious at times, but considers himself the "man of the house". He usually involves his children in several activities, such as practicing to shoot arrows or riding in a hover car without seat belts. He belittles Darryl's parenting skills, and self-confidence, either bluntly or through his children who have little respect for Darryl. Because of this, Carl and Darryl do not particularly get along, although Darryl has been talked into doing things he would not normally do, because of Carl's forceful insistence.
• Rodney Bitterman (Kath Soucie) is the eight-year-old son of Carl and Melinda Bitterman. Rodney is also the antagonist. Rodney is very mischievous and is best known for causing a lot of trouble. However, he's the smartest of his siblings and is street wise. Rodney repeatedly pesters his dad by asking stupid questions, shooting knock-knock jokes to avoid going to bed, and placing his finger an inch from his father's tools immediately after being told not to touch them. Rodney's antics always makes his sister, Megan, laugh. Besides being a menace, he can be very sympathetic, particularly to Darryl and Zoe. The sensitive side of Rodney has shown his somewhat neglected or misunderstood relationship with his dad. At one time, Rodney had tried one of Darryl's cheesy mushrooms and realized how much he cared about good food and wanted to cook. However, his father thought it was silly, so Rodney had relied on Darryl to help him. This preference to Darryl over his own dad led Darryl to pride, despite Rodney's annoying and teasing Darryl many times previously. Rodney's sensitive side also shows through his a caring and loving relationship with Zoe.
• Megan Bitterman (Kath Soucie) is Rodney's younger sister and is very close to Rodney. Megan is most commonly known for laughing out loud at anything Rodney does to pester their father. Megan is almost always seen with Rodney and keeps a huge smile on her face all the time. However, when Rodney is not around, she is seen to get very sad and cry.
• Shelby Bitterman is Carl and Melinda's youngest son who is a sociopath and is always seen carrying a fat, green, baseball bat around which he hits things with, without expression. The episode "Hurtin Inside" revealed he is four years old. He never speaks, but often communicates by pointing, and was once seen to whisper to his mom at a game of baseball in "The Bitterman Hillbillies".
• Bizzy Carey (Nicole Sullivan) is Darryl and Wanda's teenage friend who babysits Zoe on many occasions. The MacPhersons have known her since she was a girl scout. Bizzy seems to look older than she actually is, since Darryl's boss once bought Darryl's lie about her being his wife. She dislikes Drew Carey, her faux morally responsible stepfather. Wanda and Darryl many times have had to question her about her many dysfunctional boyfriends. Bizzy is blond, very thin and has a fast metabolism, as she once claimed when Wanda discovered Bizzy had been sitting on the couch all day, eating a whole bag of chocolate chip cookies, with no worry, while babysitting. It is unknown if Bizzy is her real name or not.
• Kenny (Diedrich Bader) is Darryl's smooth-talking friend and co-worker at the office. Kenny is something of a nuisance to Darryl, such as bragging about his life and family, or poking fun at Darryl's personal relationship with Wanda. Darryl normally talks to Kenny about his problems at home, to which Kenny advises with either agreeable or nonagreeable mischievous ideas. Kenny's personality is seen to be laid back and worry-free, however, he grew upset and anxious one time Darryl stopped working for a while. Even though Kenny seems to think his family's normal, it's hinted that his wife was cheating on him with a neighbor, and that he might be a neglectful father, since for one second in an episode he forgot he had a third child.
• Charlie (Phil LaMarr) is the MacPhersons' pet dog.

Recurring and minor

• Rex (Phil LaMarr) and Josie (Wendy Raquel Robinson) are an African-American couple who are close friends of Darryl and Wanda's. Rex is known for appearing in sweaters similar to what Bill Cosby wore on The Cosby Show, while Josie's favorite pastime is gardening. In the episode "God Forbid", they admit that they are Moonies.
• Sylvia (Kath Soucie) and Midge (E. G. Daily) are a lesbian couple who are close friends of Darryl and Wanda's. Sylvia has black hair, while Midge is blonde.
• Mrs. Johnson (Alice Hirson) is an elderly lady, and another one of Darryl and Wanda's neighbors. She has an unseen son named Howard, a "man-child" who still loves to read comics in his treehouse.
• Officer Murphy (Diedrich Bader) is an obese police officer who speaks with a stereotypical Irish accent.
• Dr. Gruber (Steven Weber) is the MacPhersons' big-nosed, big-eared family doctor who likes to make jokes. He appeared in two episodes straight, "Ugly Zoe" and "Wanda Proof".
• Hugh (Jim Cummings) and Maggie Wizowski (Elizabeth Perkins) are Wanda's parents who appeared in two episodes, "Rodney Moves In" and "A Baby Blues Christmas Special", along with Darryl's parents. Darryl criticized his father-in-law for telling lousy stories.
• Pauline (Arabella Field) and "Mac" MacPherson are Darryl's mother and silent father.
• Bunny (Kath Soucie) is a close friend of Wanda's, and the only character from the comic strip, besides the MacPherson/Wizowski family, to appear in this series. However, unlike in the strip, where she has a son named Bogart, she has a baby boy with long blond hair named Haget. Butch, her husband from the original comic strip, never appears in the series.

Opening sequence

The opening theme song was a shorter version of "It's All Been Done" by Barenaked Ladies, from their 1998 album Stunt. The title sequence was designed by Renegade Animation, who would later be known for Cartoon Network's Hi Hi Puffy AmiYumi,^[9] and shows the characters at the Warner Bros. studios.^{[citation needed]}

Series overview

Season 1 (2000–02)

Unaired second season

In September 2000, Warner Bros. announced that a second season would be produced.^[16] Although a second season, consisting of 13 episodes, was produced, it has never aired.^[1] Kirkman stated that the second season was nearly complete, and only needed a few final edits (such as replacing the temp music), before it was ready for release. Despite this, however, Kirkman also states that the season was written off as a loss by The WB as an accounting practice,^[17] and "will probably never see the light of day".^[18]