After working in many capacities such as a telephone operator, railway police staff and as a personal secretary to a state minister, Rao enrolled for a short-length course at Acharya N. G. Ranga Agricultural University, Rajendranagar. He did this in order to see what he could make of his life as an independent farmer, so that he may not need to work at the low-level jobs in which he was stuck due to not having an education. He successfully completed a training program in dairy and poultry farming where he had the opportunity to learn under an American teacher, Moore.[3] His first business venture was with 500 birds entrusted by Moore for tending and, soon, Rao started his own venture in a 7-acre plot, for which the funds were raised by selling his wife's jewelry.[3] The business, started in 1970, grew over the years to the present V H Group, a US$2 billion conglomerate with interests in poultry, meat, pharmaceuticals, cattle feed, sports and has presence in India, Bangladesh, United Kingdom, Singapore, Vietnam, and Brazil.[7] They hold a 99.9 percent stake in the EFL Championship team, Blackburn Rovers F.C., since 2010.[8]
When the price of eggs went down in the early 1980s, Rao gathered farmers together and founded the National Egg Coordination Committee in 1982 and was its founder chairman.[9] He was also associated with the World Poultry Science Association (WPSA) and headed its India chapter from 1993 to 1996.[3] He was one of the key figures in the organization of the World Poultry Conference in New Delhi in 1996.[4] He also founded a higher education institution, Dr B.V. Rao Institute of Poultry Management and Technology, which conducts higher courses in the subject.[10] The Government of India awarded him the civilian honour of the Padma Shri in 1990.[5] The World Poultry Science Association inducted him into their Hall of Fame in 2004 but he died before the investiture ceremony could take place.[4]