Aviv_Regev

Aviv Regev

Aviv Regev

Bioinformatician

Aviv Regev (born 11 July 1971)[1] is a computational biologist and systems biologist and Executive Vice President and Head of Genentech Research and Early Development in Genentech/Roche.[4] She is a core member (on leave) at the Broad Institute of MIT and Harvard and professor (on leave) at the Department of Biology of the Massachusetts Institute of Technology.[5] Regev is a pioneer of single cell genomics and of computational and systems biology of gene regulatory circuits. She founded and leads the Human Cell Atlas project,[6] together with Sarah Teichmann.

Quick Facts Born, Alma mater ...

Education

Regev studied at the Adi Lautman Interdisciplinary Program for Outstanding Students of Tel Aviv University, where she completed her PhD under the supervision of Eva Jablonka,[7] and Ehud Shapiro.[8]

Career and research

In 2020, Regev became the Head and Executive Vice President of Genentech Research and Early Development, based in South San Francisco, and a member of the extended Corporate Executive Committee of Roche.[9][10] Previously, she was a Core Institute Member (now on leave), Chair of the Faculty, Founding Director of the Klarman Cell Observatory and co-Director Cell Circuits Program at the Broad Institute of MIT and Harvard. She was also a professor in the Department of Biology at the Massachusetts Institute of Technology (now on leave), as well as an Investigator at the Howard Hughes Medical Institute. Regev's research[11] includes work on gene expression[12][13] (with Eran Segal and David Botstein), and the use of π-calculus to represent biochemical processes.[14][15][16] Regev's team has been a leading pioneer of single-cell genomics experimental and computational methods.[17] In 2014, she pitched the idea of the creation of Human Cell Atlas,[18] a project to describe all cell types in the human body. Regev founded the Human Cell Atlas together with Sarah Teichmann along with collaborators all over the world.[citation needed]

Single Cell Genomics

Regev's lab pioneered the development and application of many of the key experimental and computational advances for single cell and spatial genomics, especially single cell RNA-Seq (scRNA-seq).

Awards and honors

Regev is a fellow of the International Society of Computational Biology (ISCB) (2017),[19] a Helmholtz Fellow (2020),[20] and a fellow of the American Association for Cancer Research (AACR) (2021).[21] She is a member of the US National Academy of Sciences (NAS, elected 2019)[22] and of the US National Academy of Medicine (NAM, elected 2020).[23]

References

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    "Aviv Regev" (PDF). broadinstitute.org. Archived from the original (PDF) on 16 November 2017. Retrieved 2 December 2021.
  2. [2]
    Sansom, C.; Morrison Mckay, B. J. (2008). Bourne, Philip E. (ed.). "ISCB Honors David Haussler and Aviv Regev". PLOS Computational Biology. 4 (7): e1000101. Bibcode:2008PLSCB...4E0101S. doi:10.1371/journal.pcbi.1000101. PMC 2536508. PMID 18795145. Open access icon
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    Fogg, Christiana N.; Kovats, Diane E.; Berger, Bonnie (2017). "2017 ISCB Innovator Award: Aviv Regev". PLOS Computational Biology. 13 (6): e1005558. Bibcode:2017PLSCB..13E5558F. doi:10.1371/journal.pcbi.1005558. ISSN 1553-7358. PMC 5493285. PMID 28665936. Open access icon
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    GENENTECH EXECUTIVE COMMITTEE, accessed 6 August 2020.
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    "Aviv Regev at MIT". biology.mit.edu. Archived from the original on 6 April 2017. Retrieved 5 November 2017.
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    Nowogrodzki, Anna (5 July 2017). "How to build a human cell atlas". Nature. 547 (7661): 24–26. Bibcode:2017Natur.547...24N. doi:10.1038/547024a. PMID 28682347. S2CID 211067156.
  7. [7]
    Regev, A.; Lamb, M. J.; Jablonka, E. (1998). "The Role of DNA Methylation in Invertebrates: Developmental Regulation or Genome Defense?". Molecular Biology and Evolution. 15 (7): 880. doi:10.1093/oxfordjournals.molbev.a025992. ISSN 0737-4038.
  8. [8]
    Regev, A.; Shapiro, E. (2002). "Cellular abstractions: Cells as computation". Nature. 419 (6905): 343. Bibcode:2002Natur.419..343R. doi:10.1038/419343a. PMC 3842595. PMID 12353013. Closed access icon
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    Taylor, Nick Paul (11 May 2020). "Genentech lures Regev from Broad Institute to lead research and early development". fiercebiotech.com. Retrieved 25 May 2020.
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    "Changes to the Roche Enlarged Corporate Executive Committee" (Press release). Basel, Switzerland: F. Hoffmann-La Roche Ltd. globenewswire. 11 May 2020. Retrieved 25 May 2020.
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    Search Results for author Regev A on PubMed.
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    Segal, E.; Shapira, M.; Regev, A.; Pe'er, D.; Botstein, D.; Koller, D.; Friedman, N. (2003). "Module networks: Identifying regulatory modules and their condition-specific regulators from gene expression data". Nature Genetics. 34 (2): 166–176. doi:10.1038/ng1165. PMID 12740579. S2CID 6146032.
  13. [13]
    Segal, E.; Friedman, N.; Koller, D.; Regev, A. (2004). "A module map showing conditional activity of expression modules in cancer". Nature Genetics. 36 (10): 1090–1098. doi:10.1038/ng1434. PMC 2271138. PMID 15448693. Closed access icon
  14. [14]
    Regev, A.; Silverman, W.; Shapiro, E. (2001). "Representation and simulation of biochemical processes using the pi-calculus process algebra". Pacific Symposium on Biocomputing: 459–470. doi:10.1142/9789814447362_0045. ISBN 978-981-02-4515-3. PMID 11262964.
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    Priami, C.; et al. (2001). "Application of a stochastic name-passing calculus to representation and simulation of molecular processes" (PDF). Information Processing Letters. 80: 25–31. doi:10.1016/S0020-0190(01)00214-9. Closed access icon
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    Dynamic single-cell imaging of direct reprogramming reveals an early specifying event – Nature Biotechnology: Aviv Regev, Ph.D. – Career Awards at the Scientific Interface; Ab initio reconstruction of cell type–specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs – Nature Biotechnology: Aviv Regev, Ph.D. – Career Awards at the Scientific Interface.
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