George struggles to come up with ideas for a statue in an art show. Sculptor Kevin Sampson, appearing as himself, advises George to collect parts from the city dump for inspiration.

When the Brain and Buster accidentally spill Muffy’s spinach smoothie all over Arthur's new Bionic Bunny sneakers during an air hockey match, a furious Arthur loses his temper and inadvertently makes a mess of Muffy's game room. When rumors spread about the incident and his friends avoid him, Arthur seeks advice from D.W. on how to control himself.

Mrs. MacGrady is diagnosed with cancer, and Arthur and D.W. rush to support her. Francine is worried, and Muffy is initially unaware of the severity of Mrs. MacGrady's condition, but jumps to action when she realizes how to help.

NOTE: This is a remake of "The Great MacGrady" from season 13. Lance Armstrong's role as guest star in the original episode was replaced due to his involvement in doping.

D.W. befriends a teenager and imitates her, straining her friendship with Bud.

Buster falls asleep in class and has a dream where he and Mr. Ratburn switch bodies after touching an electrified dish of spanakopita. Buster, in Mr. Ratburn's body, attempts to teach his class while Mr. Ratburn, in Buster's body, figures out how to reverse the effects.