Artemisinic_aldehyde_Delta11(13)-reductase

Artemisinic aldehyde Delta11(13)-reductase

Artemisinic aldehyde Delta11(13)-reductase

Class of enzymes

Artemisinic aldehyde Delta11(13)-reductase (EC 1.3.1.92, Dbr2) is an enzyme with systematic name artemisinic aldehyde:NADP+ oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

(11R)-dihydroartemisinic aldehyde + NADP+ artemisinic aldehyde + NADPH + H+
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This enzyme i present in Artemisia annua.

References

  1. [1]
    Bertea CM, Freije JR, van der Woude H, Verstappen FW, Perk L, Marquez V, De Kraker JW, Posthumus MA, Jansen BJ, de Groot A, Franssen MC, Bouwmeester HJ (January 2005). "Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua". Planta Medica. 71 (1): 40–7. doi:10.1055/s-2005-837749. PMID 15678372.
  2. [2]
    Zhang Y, Teoh KH, Reed DW, Maes L, Goossens A, Olson DJ, Ross AR, Covello PS (August 2008). "The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua". The Journal of Biological Chemistry. 283 (31): 21501–8. doi:10.1074/jbc.M803090200. PMID 18495659.
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