In 1973, Barry Diller hired Thomopoulos at ABC to oversee prime-time programming. He was noted, among other things, for the tough position he took in dealing with the contract holdout of Suzanne Somers on the hit ABC show Three's Company,[2] and for his quick cancellation of the 1982 cult favorite Police Squad!, explaining that the show had been cancelled because, among other reasons, "it required constant attention".[3][4] In June 1983, he was named president of the broadcast group.[5] He resigned as president in 1985[5] and became chairman of United Artists Pictures,[6][7] where he supervised such productions as Betrayed, Baby Boom, and The Living Daylights.[8] In 1989, Thomopoulos formed Thomopoulos Productions, an independent production company of both motion pictures and television programs.
From 1991[9] to 1995, he was President of Amblin Television, a division of Amblin Entertainment. He was responsible for the original placement of NBC's highly acclaimed program ER, in addition to several other successful series on network television. In 1995, Thomopoulos joined International Family Entertainment, Inc. (IFE). His responsibilities included all aspects of programming for The Family Channel. He was named CEO of MTM Entertainment, Inc., a subsidiary of IFE, and was also responsible for all aspects of MTM Television and MTM Distribution.[10]
Thomopoulos was chairman and CEO of artist Thomas Kinkade's Media Arts Group[11] from June 2001 to January 2004. He subsequently founded Morning Light Productions.[12]